FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taipale, J.
Right arrow Articles by Keski-Oja, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taipale, J.
Right arrow Articles by Keski-Oja, J.

The FASEB Journal, Vol 11, 51-59, Copyright © 1997 by The Federation of American Societies for Experimental Biology

REVIEWS

Growth factors in the extracellular matrix

J Taipale and J Keski-Oja
Department of Virology, University of Helsinki, Finland.

Much recent research has focused on the study of the expression of growth factor genes and on the identification of growth factor signaling mechanisms inside cells. However, growth factor signaling can also be regulated outside of cells by extracellular matrix proteins and proteolytic enzymes. The ability of extracellular proteins to process complex information in the absence of new protein synthesis is illustrated in blood clotting and complement pathways. An increasing number of growth factors, including IGFs, FGFs, TGF-beta's, and HGF, have been found to associate with the extracellular matrix proteins or with heparan sulfate. Rapid and localized changes in the activity of these factors can be induced by release from matrix storage and/or by activation of latent forms. These growth factors, in turn, control cell proliferation, differentiation, and synthesis and remodeling of the extracellular matrix. It is therefore likely that much of the information processing necessary for construction of complex multicellular organisms occurs in the extracellular environment. This suggests that extracellular matrix plays a major role in the control of growth factor signaling.


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
R. G. Thorne, A. Lakkaraju, E. Rodriguez-Boulan, and C. Nicholson
In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate
PNAS, June 17, 2008; 105(24): 8416 - 8421.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
Yan Wen, Y.-Y. Zhao, M. L. Polan, and B. Chen
Effect of Relaxin on TGF-{beta}1 Expression in Cultured Vaginal Fibroblasts From Women With Stress Urinary Incontinence
Reproductive Sciences, March 1, 2008; 15(3): 312 - 320.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
S. C. Bryer, G. Fantuzzi, N. Van Rooijen, and T. J. Koh
Urokinase-Type Plasminogen Activator Plays Essential Roles in Macrophage Chemotaxis and Skeletal Muscle Regeneration
J. Immunol., January 15, 2008; 180(2): 1179 - 1188.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
R. A. Dean, G. S. Butler, Y. Hamma-Kourbali, J. Delbe, D. R. Brigstock, J. Courty, and C. M. Overall
Identification of Candidate Angiogenic Inhibitors Processed by Matrix Metalloproteinase 2 (MMP-2) in Cell-Based Proteomic Screens: Disruption of Vascular Endothelial Growth Factor (VEGF)/Heparin Affin Regulatory Peptide (Pleiotrophin) and VEGF/Connective Tissue Growth Factor Angiogenic Inhibitory Complexes by MMP-2 Proteolysis
Mol. Cell. Biol., December 15, 2007; 27(24): 8454 - 8465.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
F. M.D. Tholozan, C. Gribbon, Z. Li, M. W. Goldberg, A. R. Prescott, N. McKie, and R. A. Quinlan
FGF-2 Release from the Lens Capsule by MMP-2 Maintains Lens Epithelial Cell Viability
Mol. Biol. Cell, November 1, 2007; 18(11): 4222 - 4231.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. C. Bryer and T. J. Koh
The urokinase-type plasminogen activator receptor is not required for skeletal muscle inflammation or regeneration
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1152 - R1158.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Skibinski, J. S. Elborn, and M. Ennis
Bronchial epithelial cell growth regulation in fibroblast cocultures: the role of hepatocyte growth factor
Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L69 - L76.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
C. Lamagna, M. Aurrand-Lions, and B. A. Imhof
Dual role of macrophages in tumor growth and angiogenesis
J. Leukoc. Biol., October 1, 2006; 80(4): 705 - 713.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Basche, D. L. Gustafson, S. N. Holden, C. L. O'Bryant, L. Gore, S. Witta, M. K. Schultz, M. Morrow, A. Levin, B. R. Creese, et al.
A Phase I Biological and Pharmacologic Study of the Heparanase Inhibitor PI-88 in Patients with Advanced Solid Tumors.
Clin. Cancer Res., September 15, 2006; 12(18): 5471 - 5480.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
H. C. Nystrom, P. Lindblom, A. Wickman, I. Andersson, J. Norlin, J. Faldt, P. Lindahl, O. Skott, M. Bjarnegard, S. M. Fitzgerald, et al.
Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries
Cardiovasc Res, August 1, 2006; 71(3): 557 - 565.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. Li, F. Ding, L. Zhang, Z. Liu, Y. Wu, A. Luo, M. Wu, M. Wang, Q. Zhan, and Z. Liu
Overexpression of Stefin A in Human Esophageal Squamous Cell Carcinoma Cells Inhibits Tumor Cell Growth, Angiogenesis, Invasion, and Metastasis
Clin. Cancer Res., December 15, 2005; 11(24): 8753 - 8762.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. M. Stevens and J. H. George
Exploring and Engineering the Cell Surface Interface
Science, November 18, 2005; 310(5751): 1135 - 1138.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. S. Rao, C. Gondi, C. Chetty, S. Chittivelu, P. A. Joseph, and S. S. Lakka
Inhibition of invasion, angiogenesis, tumor growth, and metastasis by adenovirus-mediated transfer of antisense uPAR and MMP-9 in non-small cell lung cancer cells
Mol. Cancer Ther., September 1, 2005; 4(9): 1399 - 1408.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. L. Dallas, P. Sivakumar, C. J. P. Jones, Q. Chen, D. M. Peters, D. F. Mosher, M. J. Humphries, and C. M. Kielty
Fibronectin Regulates Latent Transforming Growth Factor-{beta} (TGF{beta}) by Controlling Matrix Assembly of Latent TGF{beta}-binding Protein-1
J. Biol. Chem., May 13, 2005; 280(19): 18871 - 18880.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Freeman, L. Liu, M. G. Banwell, K. J. Brown, A. Bezos, V. Ferro, and C. R. Parish
Use of Sulfated Linked Cyclitols as Heparan Sulfate Mimetics to Probe the Heparin/Heparan Sulfate Binding Specificity of Proteins
J. Biol. Chem., March 11, 2005; 280(10): 8842 - 8849.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
T. Li, L. Sun, N. Miller, T. Nicklee, J. Woo, L. Hulse-Smith, M.-S. Tsao, R. Khokha, L. Martin, and N. Boyd
The Association of Measured Breast Tissue Characteristics with Mammographic Density and Other Risk Factors for Breast Cancer
Cancer Epidemiol. Biomarkers Prev., February 1, 2005; 14(2): 343 - 349.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
M F Smith, C G Gutierrez, W A Ricke, D G Armstrong, and R Webb
Production of matrix metalloproteinases by cultured bovine theca and granulosa cells
Reproduction, January 1, 2005; 129(1): 75 - 87.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. G. Thorne, S. Hrabetova, and C. Nicholson
Diffusion of Epidermal Growth Factor in Rat Brain Extracellular Space Measured by Integrative Optical Imaging
J Neurophysiol, December 1, 2004; 92(6): 3471 - 3481.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. Strup-Perrot, D. Mathe, C. Linard, D. Violot, F. Milliat, A. Francois, J. Bourhis, and M.-C. Vozenin-Brotons
Global gene expression profiles reveal an increase in mRNA levels of collagens, MMPs, and TIMPs in late radiation enteritis
Am J Physiol Gastrointest Liver Physiol, October 1, 2004; 287(4): G875 - G885.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
J. P. Annes, Y. Chen, J. S. Munger, and D. B. Rifkin
Integrin {alpha}V{beta}6-mediated activation of latent TGF-{beta} requires the latent TGF-{beta} binding protein-1
J. Cell Biol., June 7, 2004; 165(5): 723 - 734.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
B. Santiago-Josefat, S. Mulero-Navarro, S. L. Dallas, and P. M. Fernandez-Salguero
Overexpression of latent transforming growth factor-{beta} binding protein 1 (LTBP-1) in dioxin receptor-null mouse embryo fibroblasts
J. Cell Sci., February 22, 2004; 117(6): 849 - 859.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
V. Levidiotis, C. Freeman, C. Tikellis, M. E. Cooper, and D. A. Power
Heparanase Is Involved in the Pathogenesis of Proteinuria as a Result of Glomerulonephritis
J. Am. Soc. Nephrol., January 1, 2004; 15(1): 68 - 78.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Takei, Y. Ozawa, M. Sato, A. Watanabe, and T. Tabata
Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans
Development, January 1, 2004; 131(1): 73 - 82.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. Margosio, D. Marchetti, V. Vergani, R. Giavazzi, M. Rusnati, M. Presta, and G. Taraboletti
Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2
Blood, December 15, 2003; 102(13): 4399 - 4406.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. M. de Mestre, L. M. Khachigian, F. S. Santiago, M. A. Staykova, and M. D. Hulett
Regulation of Inducible Heparanase Gene Transcription in Activated T Cells by Early Growth Response 1
J. Biol. Chem., December 12, 2003; 278(50): 50377 - 50385.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. R. Morris, J. Drawbridge, and M. S. Steinberg
Axolotl pronephric duct migration requires an epidermally derived, laminin 1-containing extracellular matrix and the integrin receptor {alpha}6{beta}1
Development, December 1, 2003; 130(23): 5601 - 5608.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Ono, T. Shimizugawa, M. Shimamura, K. Yoshida, C. Noji-Sakikawa, Y. Ando, R. Koishi, and H. Furukawa
Protein Region Important for Regulation of Lipid Metabolism in Angiopoietin-like 3 (ANGPTL3): ANGPTL3 IS CLEAVED AND ACTIVATED IN VIVO
J. Biol. Chem., October 24, 2003; 278(43): 41804 - 41809.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. J. Evans, M. V. Fanucchi, G. L. Baker, L. S. Van Winkle, L. M. Pantle, S. J. Nishio, E. S. Schelegle, L. J. Gershwin, L. A. Miller, D. M. Hyde, et al.
Atypical development of the tracheal basement membrane zone of infant rhesus monkeys exposed to ozone and allergen
Am J Physiol Lung Cell Mol Physiol, October 1, 2003; 285(4): L931 - L939.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Araujo, E. Negreiros, and E. Bier
Integrins modulate Sog activity in the Drosophila wing
Development, August 15, 2003; 130(16): 3851 - 3864.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
E. Mazzoni, A. Adam, E. Bal de Kier Joffe, and J. A. Aguirre-Ghiso
Immortalized Mammary Epithelial Cells Overexpressing Protein Kinase C {gamma} Acquire a Malignant Phenotype and Become Tumorigenic in Vivo
Mol. Cancer Res., August 1, 2003; 1(10): 776 - 787.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Herget, J. Novotna, J. Bibova, V. Povysilova, M. Vankova, and V. Hampl
Metalloproteinase inhibition by Batimastat attenuates pulmonary hypertension in chronically hypoxic rats
Am J Physiol Lung Cell Mol Physiol, July 1, 2003; 285(1): L199 - L208.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Luque, D. R. Carpizo, and M. L. Iruela-Arispe
ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165
J. Biol. Chem., June 20, 2003; 278(26): 23656 - 23665.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. J. Evans, M. V. Fanucchi, L. S. Van Winkle, G. L. Baker, A. E. Murphy, S. J. Nishio, P. L. Sannes, and C. G. Plopper
Fibroblast growth factor-2 during postnatal development of the tracheal basement membrane zone
Am J Physiol Lung Cell Mol Physiol, December 1, 2002; 283(6): L1263 - L1270.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R.-B. Yang, C. K. D. Ng, S. M. Wasserman, S. D. Colman, S. Shenoy, F. Mehraban, L. G. Komuves, J. E. Tomlinson, and J. N. Topper
Identification of a Novel Family of Cell-surface Proteins Expressed in Human Vascular Endothelium
J. Biol. Chem., November 22, 2002; 277(48): 46364 - 46373.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. R. Adams
Exercise Effects on Muscle Insulin Signaling and Action: Invited Review: Autocrine/paracrine IGF-I and skeletal muscle adaptation
J Appl Physiol, September 1, 2002; 93(3): 1159 - 1167.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. C Wanstall, A. Gambino, T. K Jeffery, M. M Cahill, D. Bellomo, N. K Hayward, and G. F Kay
Vascular endothelial growth factor-B-deficient mice show impaired development of hypoxic pulmonary hypertension
Cardiovasc Res, August 1, 2002; 55(2): 361 - 368.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Ruehl, R. Somasundaram, I. Schoenfelder, R. W. Farndale, C. G. Knight, M. Schmid, R. Ackermann, E. O. Riecken, M. Zeitz, and D. Schuppan
The Epithelial Mitogen Keratinocyte Growth Factor Binds to Collagens via the Consensus Sequence Glycine-Proline-Hydroxyproline
J. Biol. Chem., July 19, 2002; 277(30): 26872 - 26878.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. K. Winkler and J. L. Fowlkes
Metalloproteinase and growth factor interactions: do they play a role in pulmonary fibrosis?
Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L1 - L11.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. L. Dallas, J. L. Rosser, G. R. Mundy, and L. F. Bonewald
Proteolysis of Latent Transforming Growth Factor-beta (TGF-beta )-binding Protein-1 by Osteoclasts. A CELLULAR MECHANISM FOR RELEASE OF TGF-beta FROM BONE MATRIX
J. Biol. Chem., June 7, 2002; 277(24): 21352 - 21360.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. J. DiCamillo, I. Carreras, M. V. Panchenko, P. J. Stone, M. A. Nugent, J. A. Foster, and M. P. Panchenko
Elastase-released Epidermal Growth Factor Recruits Epidermal Growth Factor Receptor and Extracellular Signal-regulated Kinases to Down-regulate Tropoelastin mRNA in Lung Fibroblasts
J. Biol. Chem., May 17, 2002; 277(21): 18938 - 18946.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Grenier, S. Chollet-Martin, B. Crestani, C. Delarche, J. El Benna, A. Boutten, V. Andrieu, G. Durand, M.-A. Gougerot-Pocidalo, M. Aubier, et al.
Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophils
Blood, April 15, 2002; 99(8): 2997 - 3004.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Y. Li, T. Kadokami, P. Wang, C. F. McTiernan, and A. M. Feldman
MMP inhibition modulates TNF-alpha transgenic mouse phenotype early in the development of heart failure
Am J Physiol Heart Circ Physiol, March 1, 2002; 282(3): H983 - H989.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
F.-X. Jiang, E. G. Stanley, L. J. Gonez, and L. C. Harrison
Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells
J. Cell Sci., February 15, 2002; 115(4): 753 - 760.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Kuniyasu, N. Oue, M. Tsutsumi, E. Tahara, and W. Yasui
Heparan Sulfate Enhances Invasion by Human Colon Carcinoma Cell Lines through Expression of CD44 Variant Exon 3
Clin. Cancer Res., December 1, 2001; 7(12): 4067 - 4072.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. Frisdal, V. Gest, A. Vieillard-Baron, M. Levame, H. Lepetit, S. Eddahibi, C. Lafuma, A. Harf, S. Adnot, and M-;P. d'Ortho
Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension
Eur. Respir. J., November 1, 2001; 18(5): 838 - 845.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
S. Saika, T. Miyamoto, T. Tanaka, I. Ishida, Y. Ohnishi, and A. Ooshima
Latent TGFbeta binding protein-1 and fibrillin-1 in human capsular opacification and in cultured lens epithelial cells
Br. J. Ophthalmol., November 1, 2001; 85(11): 1362 - 1366.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
E. Arteaga-Solis, B. Gayraud, S. Y. Lee, L. Shum, L. Sakai, and F. Ramirez
Regulation of limb patterning by extracellular microfibrils
J. Cell Biol., July 23, 2001; 154(2): 275 - 282.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
K. A. LINDSTEDT, Y. WANG, N. SHIOTA, J. SAARINEN, M. HYYTIAINEN, J. O. KOKKONEN, J. KESKI-OJA, and P. T. KOVANEN
Activation of paracrine TGF-{beta}1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase
FASEB J, June 1, 2001; 15(8): 1377 - 1388.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
O. N. El-Assal, A. Yamanoi, T. Ono, H. Kohno, and N. Nagasue
The Clinicopathological Significance of Heparanase and Basic Fibroblast Growth Factor Expressions in Hepatocellular Carcinoma
Clin. Cancer Res., May 1, 2001; 7(5): 1299 - 1305.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
L. Yan and M. A. Moses
A Case of Tumor Betrayal : Biphasic Effects of TIMP-1 on Burkitt's Lymphoma
Am. J. Pathol., April 1, 2001; 158(4): 1185 - 1190.
[Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C Unsold, M Hyytiainen, L Bruckner-Tuderman, and J Keski-Oja
Latent TGF-beta binding protein LTBP-1 contains three potential extracellular matrix interacting domains
J. Cell Sci., January 1, 2001; 114(1): 187 - 197.
[Abstract] [PDF]

Home page
 BloodHome page
C. Seidel, M. Borset, O. Hjertner, D. Cao, N. Abildgaard, H. Hjorth-Hansen, R. D. Sanderson, A. Waage, and A. Sundan
High levels of soluble syndecan-1 in myeloma-derived bone marrow: modulation of hepatocyte growth factor activity
Blood, November 1, 2000; 96(9): 3139 - 3146.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. O. Fortunel, A. Hatzfeld, and J. A. Hatzfeld
Transforming growth factor-beta : pleiotropic role in the regulation of hematopoiesis
Blood, September 15, 2000; 96(6): 2022 - 2036.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Bioactive and Compatible PolymersHome page
Md. Muniruzzaman, Y. Tabata, and Y. Ikada
Physicochemical Properties of Basic Fibroblast Growth Factor-Gelatin Complex
Journal of Bioactive and Compatible Polymers, September 1, 2000; 15(5): 365 - 375.
[Abstract] [PDF]

Home page
 Circ. Res.Home page
A. Vieillard-Baron, E. Frisdal, S. Eddahibi, I. Deprez, A. H. Baker, A. C. Newby, P. Berger, M. Levame, B. Raffestin, S. Adnot, et al.
Inhibition of Matrix Metalloproteinases by Lung TIMP-1 Gene Transfer or Doxycycline Aggravates Pulmonary Hypertension in Rats
Circ. Res., September 1, 2000; 87(5): 418 - 425.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Salek-Ardakani, J. R. Arrand, D. Shaw, and M. Mackett
Heparin and heparan sulfate bind interleukin-10 and modulate its activity
Blood, September 1, 2000; 96(5): 1879 - 1888.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Rameshwar, R. Narayanan, J. Qian, T. N. Denny, C. Colon, and P. Gascon
NF-{kappa}B as a Central Mediator in the Induction of TGF-{beta} in Monocytes from Patients with Idiopathic Myelofibrosis: An Inflammatory Response Beyond the Realm of Homeostasis
J. Immunol., August 15, 2000; 165(4): 2271 - 2277.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Betsuyaku, Y. Fukuda, W. C. Parks, J. M. Shipley, and R. M. Senior
Gelatinase B Is Required for Alveolar Bronchiolization after Intratracheal Bleomycin
Am. J. Pathol., August 1, 2000; 157(2): 525 - 535.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. Saharinen and J. Keski-Oja
Specific Sequence Motif of 8-Cys Repeats of TGF-beta Binding Proteins, LTBPs, Creates a Hydrophobic Interaction Surface for Binding of Small Latent TGF-beta
Mol. Biol. Cell, August 1, 2000; 11(8): 2691 - 2704.
[Abstract] [Full Text]

Home page
 GlycobiologyHome page
K. Mani, M. Jonsson, G. Edgren, M. Belting, and L.-A. Fransson
A novel role for nitric oxide in the endogenous degradation of heparan sulfate during recycling of glypican-1 in vascular endothelial cells
Glycobiology, June 1, 2000; 10(6): 577 - 586.
[Abstract] [Full Text] [PDF]

Home page