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The FASEB Journal, Vol 10, 1025-1030, Copyright © 1996 by The Federation of American Societies for Experimental Biology

REVIEWS

Retinoid differentiation therapy in promyelocytic leukemia

C Chomienne, P Fenaux and L Degos
Hopital Saint-Louis, Institute of Hematology, Paris, France.

Acute promyelocytic leukemia (APL) is a specific type of acute myeloid leukemia characterized by the morphology of the blast cells, a specific t(15;17) translocation, and risks of definite coagulopathy. Recently this leukemia was further characterized by an exquisite sensitivity to all-trans retinoic acid's differentiation effect and the production of a fusion gene altering the gene of RARalpha and a novel gene PML. In vivo differentiation therapy with retinoids in APL patients follows strict guidelines related both to the APL cell and the biodisposal of all-trans retinoic acid.


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Copyright © 1996 by The Federation of American Societies for Experimental Biology.