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The FASEB Journal, Vol 10, 598-614, Copyright © 1996 by The Federation of American Societies for Experimental Biology
REVIEWS |
RV Iozzo and AD Murdoch
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
This review focuses on the extracellular proteoglycans. Special emphasis is placed on the structural features of their protein cores, their gene organization, and their transcriptional control. A simplified nomenclature comprising two broad groups of extracellular proteoglycans is offered: the small leucine-rich proteoglycans or SLRPs, pronounced "slurps, " and the modular proteoglycans. The first group encompasses at least five distinct members of a gene family characterized by a central domain composed of leucine-rich repeats flanked by two cysteine-rich regions. The second group consists of those proteoglycans whose unifying feature is the assembly of various protein modules in a relatively elongated and often highly glycosylated structure. This group is quite heterogeneous and includes a distinct family of proteoglycans, the "hyalectans," that bind hyaluronan and contain a C-type lectin motif that is likely to bind carbohydrates, and a less distinct group that contains structural homologies but lacks hyaluronan-binding properties or lectin-like domains.
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D. R. Keene, C. C. Ridgway, and R. V. Iozzo Type VI Microfilaments Interact with a Specific Region of Banded Collagen Fibrils in Skin J. Histochem. Cytochem., February 1, 1998; 46(2): 215 - 220. [Abstract] [Full Text] |
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T. R. Kyriakides, Y.-H. Zhu, L. T. Smith, S. D. Bain, Z. Yang, M. T. Lin, K. G. Danielson, R. V. Iozzo, M. LaMarca, C. E. McKinney, et al. Mice That Lack Thrombospondin 2 Display Connective Tissue Abnormalities That Are Associated with Disordered Collagen Fibrillogenesis, an Increased Vascular Density, and a Bleeding Diathesis J. Cell Biol., January 26, 1998; 140(2): 419 - 430. [Abstract] [Full Text] [PDF] |
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M.M. Klinger, F. Rahemtulla, C.W. Prince, L.C. Lucas, and J.E. Lemons Proteoglycans At the Bone-Implant Interface Critical Reviews in Oral Biology & Medicine, January 1, 1998; 9(4): 449 - 463. [Abstract] [Full Text] [PDF] |
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E. S. Tasheva, L. M. Corpuz, J. L. Funderburgh, and G. W. Conrad Differential Splicing and Alternative Polyadenylation Generate Multiple Mimecan mRNA Transcripts J. Biol. Chem., December 19, 1997; 272(51): 32551 - 32556. [Abstract] [Full Text] [PDF] |
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Y. Liang, M. Haring, P. J. Roughley, R. K. Margolis, and R. U. Margolis Glypican and Biglycan in the Nuclei of Neurons and Glioma Cells: Presence of Functional Nuclear Localization Signals and Dynamic Changes in Glypican During the Cell Cycle J. Cell Biol., November 17, 1997; 139(4): 851 - 864. [Abstract] [Full Text] [PDF] |
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S. Yamauchi, H. Cheng, P. Neame, B. Caterson, and M. Yamauchi Identification, Partial Characterization, and Distribution of Versican and Link Protein in Bovine Dental Pulp Journal of Dental Research, November 1, 1997; 76(11): 1730 - 1736. [Abstract] [PDF] |
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U. Rauch, A. Clement, C. Retzler, L. Frohlich, R. Fassler, W. Gohring, and A. Faissner Mapping of a Defined Neurocan Binding Site to Distinct Domains of Tenascin-C J. Biol. Chem., October 24, 1997; 272(43): 26905 - 26912. [Abstract] [Full Text] [PDF] |
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T. Ehnis, W. Dieterich, M. Bauer, H. Kresse, and D. Schuppan Localization of a Binding Site for the Proteoglycan Decorin on Collagen XIV (Undulin) J. Biol. Chem., August 15, 1997; 272(33): 20414 - 20419. [Abstract] [Full Text] [PDF] |
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H. J. Johnson, L. Rosenberg, H. U. Choi, S. Garza, M. Hook, and P. J. Neame Characterization of Epiphycan, a Small Proteoglycan with a Leucine-rich Repeat Core Protein J. Biol. Chem., July 25, 1997; 272(30): 18709 - 18717. [Abstract] [Full Text] [PDF] |
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H. Kresse, C. Liszio, E. Schonherr, and L. W. Fisher Critical Role of Glutamate in a Central Leucine-rich Repeat of Decorin for Interaction with Type I Collagen J. Biol. Chem., July 18, 1997; 272(29): 18404 - 18410. [Abstract] [Full Text] [PDF] |
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D. Marchetti, S. Liu, W. C. Spohn, and D. D. Carson Heparanase and a Synthetic Peptide of Heparan Sulfate-interacting Protein Recognize Common Sites on Cell Surface and Extracellular Matrix Heparan Sulfate J. Biol. Chem., June 20, 1997; 272(25): 15891 - 15897. [Abstract] [Full Text] [PDF] |
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L. Nelimarkka, V. Kainulainen, E. Schonherr, S. Moisander, M. Jortikka, M. Lammi, K. Elenius, M. Jalkanen, and H. Jarvelainen Expression of Small Extracellular Chondroitin/Dermatan Sulfate Proteoglycans Is Differentially Regulated in Human Endothelial Cells J. Biol. Chem., May 9, 1997; 272(19): 12730 - 12737. [Abstract] [Full Text] [PDF] |
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R. K. Batra, J. C. Olsen, D. K. Hoganson, B. Caterson, and R. C. Boucher Retroviral Gene Transfer Is Inhibited by Chondroitin Sulfate Proteoglycans/Glycosaminoglycans in Malignant Pleural Effusions J. Biol. Chem., May 2, 1997; 272(18): 11736 - 11743. [Abstract] [Full Text] [PDF] |
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F. Deak, D. Piecha, C. Bachrati, M. Paulsson, and I. Kiss Primary Structure and Expression of Matrilin-2, the Closest Relative of Cartilage Matrix Protein within the von Willebrand Factor Type A-like Module Superfamily J. Biol. Chem., April 4, 1997; 272(14): 9268 - 9274. [Abstract] [Full Text] [PDF] |
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R. V. Iozzo, J. Pillarisetti, B. Sharma, A. D. Murdoch, K. G. Danielson, J. Uitto, and A. Mauviel Structural and Functional Characterization of the Human Perlecan Gene Promoter. TRANSCRIPTIONAL ACTIVATION BY TRANSFORMING GROWTH FACTOR-beta VIA A NUCLEAR FACTOR 1-BINDING ELEMENT J. Biol. Chem., February 21, 1997; 272(8): 5219 - 5228. [Abstract] [Full Text] [PDF] |
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K. G. Danielson, H. Baribault, D. F. Holmes, H. Graham, K. E. Kadler, and R. V. Iozzo Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility J. Cell Biol., February 10, 1997; 136(3): 729 - 743. [Abstract] [Full Text] [PDF] |
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I. T. Weber, R. W. Harrison, and R. V. Iozzo Model Structure of Decorin and Implications for Collagen Fibrillogenesis J. Biol. Chem., December 13, 1996; 271(50): 31767 - 31770. [Abstract] [Full Text] [PDF] |
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U. K. Blaschke, E. Hedbom, and P. Bruckner Distinct Isoforms of Chicken Decorin Contain Either One or Two Dermatan Sulfate Chains J. Biol. Chem., November 29, 1996; 271(48): 30347 - 30353. [Abstract] [Full Text] [PDF] |
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C. Retzler, W. Gohring, and U. Rauch Analysis of Neurocan Structures Interacting with the Neural Cell Adhesion Molecule N-CAM J. Biol. Chem., November 1, 1996; 271(44): 27304 - 27310. [Abstract] [Full Text] [PDF] |
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A. Mauviel, K. Korang, M. Santra, D. Tewari, J. Uitto, and R. V. Iozzo Identification of a Bimodal Regulatory Element Encompassing a Canonical AP-1 Binding Site in the Proximal Promoter Region of the Human Decorin Gene J. Biol. Chem., October 4, 1996; 271(40): 24824 - 24829. [Abstract] [Full Text] [PDF] |
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A. De Luca, M. Santra, A. Baldi, A. Giordano, and R. V. Iozzo Decorin-induced Growth Suppression Is Associated with Up-regulation of p21, an Inhibitor of Cyclin-dependent Kinases J. Biol. Chem., August 2, 1996; 271(31): 18961 - 18965. [Abstract] [Full Text] [PDF] |
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A. I. Olin, M. Morgelin, T. Sasaki, R. Timpl, D. Heinegard, and A. Aspberg The Proteoglycans Aggrecan and Versican Form Networks with Fibulin-2 through Their Lectin Domain Binding J. Biol. Chem., January 5, 2001; 276(2): 1253 - 1261. [Abstract] [Full Text] [PDF] |
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J. Hirose, H. Kawashima, O. Yoshie, K. Tashiro, and M. Miyasaka Versican Interacts with Chemokines and Modulates Cellular Responses J. Biol. Chem., February 9, 2001; 276(7): 5228 - 5234. [Abstract] [Full Text] [PDF] |
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E. Bengtsson, A. Aspberg, D. Heinegard, Y. Sommarin, and D. Spillmann The Amino-terminal Part of PRELP Binds to Heparin and Heparan Sulfate J. Biol. Chem., December 22, 2000; 275(52): 40695 - 40702. [Abstract] [Full Text] [PDF] |
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