FASEB J. Pierce now sold as Thermo Scientific
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taub, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taub, R.

The FASEB Journal, Vol 10, 413-427, Copyright © 1996 by The Federation of American Societies for Experimental Biology

REVIEWS

Liver regeneration 4: transcriptional control of liver regeneration

R Taub
Department of Genetics and Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6145, USA.

Determining what factors are responsible for initiating regeneration following partial hepatectomy or toxic damage, and how the liver maintains differentiated functions while the hepatocytes are undergoing cellular proliferation are central issues in understanding the molecular bases of liver regeneration. Examination of the transcriptional milieu in the regenerating liver provides clues to the answers to these questions. Growth factor-generated intracellular signals that trigger liver regeneration result in activation via posttranslational modifications of latent, normally inactive transcription factors that preexist in the liver. Two transcription factors that are activated by this mechanism include posthepatectomy factor/nuclear factor-kappa B) and Stat3. Because cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-l (IL-1), and IL-6 can induce these factors in the liver, the finding of activated Stat3 and PHF/NF-kappa B suggests that these cytokines may play a role in some aspects of growth regulation during liver regeneration. Rapidly induced transcription factors, Stat3, PHF/NF-kappa B, and others are responsible for activation of the primary growth response or immediate- early genes, which play a role in regulating later phases of cell growth in regenerating liver and other mitogen-activated cells. Immediate-early genes encode many members of diverse transcription factor families including the Jun-Fos-LRF-1, nuclear receptor, and myc families to name a few. In this way a transcriptional cascade is established during the G1 phase of liver regeneration. Coexisting with these induced factors are liver-specific transcription factors such as the CAAT enhancer binding proteins and hepatocyte nuclear factors, which may interact with growth-induced factors to help the liver maintain metabolic homeostasis during regeneration. As a result the liver is able to accomplish the goals of reestablishing its mass while it maintains its functional capacity during regeneration.


This article has been cited by other articles:


Home page
 Genes Dev.Home page
T. Nakagawa, T. Kajitani, S. Togo, N. Masuko, H. Ohdan, Y. Hishikawa, T. Koji, T. Matsuyama, T. Ikura, M. Muramatsu, et al.
Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation
Genes & Dev., January 1, 2008; 22(1): 37 - 49.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Natarajan, B. Wagner, and M. Sibilia
The EGF receptor is required for efficient liver regeneration
PNAS, October 23, 2007; 104(43): 17081 - 17086.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
N. Masumoto, C. Tateno, A. Tachibana, R. Utoh, Y. Morikawa, T. Shimada, H. Momisako, T. Itamoto, T. Asahara, and K. Yoshizato
GH enhances proliferation of human hepatocytes grafted into immunodeficient mice with damaged liver
J. Endocrinol., September 1, 2007; 194(3): 529 - 537.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Bailly-Maitre, E. Bard-Chapeau, F. Luciano, N. Droin, J.-M. Bruey, B. Faustin, C. Kress, J. M. Zapata, and J. C. Reed
Mice Lacking bi-1 Gene Show Accelerated Liver Regeneration
Cancer Res., February 15, 2007; 67(4): 1442 - 1450.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. Guo, M. D. Sans, G. T. Gurda, S.-H. Lee, S. A. Ernst, and J. A. Williams
Induction of early response genes in trypsin inhibitor-induced pancreatic growth
Am J Physiol Gastrointest Liver Physiol, February 1, 2007; 292(2): G667 - G677.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Y. P. Turmelle, O. Shikapwashya, S. Tu, P. W. Hruz, Q. Yan, and D. A. Rudnick
Rosiglitazone inhibits mouse liver regeneration
FASEB J, December 1, 2006; 20(14): 2609 - 2611.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Columbano, M. Pibiri, M. Deidda, C. Cossu, T. S. Scanlan, G. Chiellini, S. Muntoni, and G. M. Ledda-Columbano
The Thyroid Hormone Receptor-{beta} Agonist GC-1 Induces Cell Proliferation in Rat Liver and Pancreas
Endocrinology, July 1, 2006; 147(7): 3211 - 3218.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
H. M. Mehendale
Tissue Repair: An Important Determinant of Final Outcome of Toxicant-Induced Injury
Toxicol Pathol, January 1, 2005; 33(1): 41 - 51.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Liao, O. N. Shikapwashya, E. Shteyer, B. K. Dieckgraefe, P. W. Hruz, and D. A. Rudnick
Delayed Hepatocellular Mitotic Progression and Impaired Liver Regeneration in Early Growth Response-1-deficient Mice
J. Biol. Chem., October 8, 2004; 279(41): 43107 - 43116.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
U. M. Apte, R. Mcree, and S. K. Ramaiah
Hepatocyte Proliferation is the Possible Mechanism for the Transient Decrease in Liver Injury During Steatosis Stage of Alcoholic Liver Disease
Toxicol Pathol, August 1, 2004; 32(5): 567 - 576.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Borowiak, A. N. Garratt, T. Wustefeld, M. Strehle, C. Trautwein, and C. Birchmeier
Met provides essential signals for liver regeneration
PNAS, July 20, 2004; 101(29): 10608 - 10613.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. Sandoval, J. L. Rodriguez, G. Tur, G. Serviddio, J. Pereda, A. Boukaba, J. Sastre, L. Torres, L. Franco, and G. Lopez-Rodas
RNAPol-ChIP: a novel application of chromatin immunoprecipitation to the analysis of real-time gene transcription
Nucleic Acids Res., June 24, 2004; 32(11): e88 - e88.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Chen, Y. Li, K. Wei, L. Li, W. Liu, Y. Zhu, Z. Qiu, and F. He
The Potentiation Role of Hepatopoietin on Activator Protein-1 Is Dependent on Its Sulfhydryl Oxidase Activity
J. Biol. Chem., December 5, 2003; 278(49): 49022 - 49030.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
C. W. Strey, M. Markiewski, D. Mastellos, R. Tudoran, L. A. Spruce, L. E. Greenbaum, and J. D. Lambris
The Proinflammatory Mediators C3a and C5a Are Essential for Liver Regeneration
J. Exp. Med., September 15, 2003; 198(6): 913 - 923.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Arai, O. Yokosuka, T. Chiba, F. Imazeki, M. Kato, J. Hashida, Y. Ueda, S. Sugano, K. Hashimoto, H. Saisho, et al.
Gene Expression Profiling Reveals the Mechanism and Pathophysiology of Mouse Liver Regeneration
J. Biol. Chem., August 8, 2003; 278(32): 29813 - 29818.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. I. Leu, M. A. S. Crissey, L. E. Craig, and R. Taub
Impaired Hepatocyte DNA Synthetic Response Posthepatectomy in Insulin-Like Growth Factor Binding Protein 1-Deficient Mice with Defects in C/EBP{beta} and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Regulation
Mol. Cell. Biol., February 15, 2003; 23(4): 1251 - 1259.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Banerjee, C. Bueso-Ramos, and B. B. Aggarwal
Suppression of 7,12-Dimethylbenz(a)anthracene-induced Mammary Carcinogenesis in Rats by Resveratrol: Role of Nuclear Factor-{kappa}B, Cyclooxygenase 2, and Matrix Metalloprotease 9
Cancer Res., September 1, 2002; 62(17): 4945 - 4954.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. I. Su, L. G. Guidotti, J. P. Pezacki, F. V. Chisari, and P. G. Schultz
Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice
PNAS, August 20, 2002; 99(17): 11181 - 11186.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Macias-Silva, W. Li, J. I. Leu, M. A. S. Crissey, and R. Taub
Up-regulated Transcriptional Repressors SnoN and Ski Bind Smad Proteins to Antagonize Transforming Growth Factor-beta Signals during Liver Regeneration
J. Biol. Chem., August 2, 2002; 277(32): 28483 - 28490.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. P. Anderson, C. S. Dunn, R. C. Cattley, and J.C. Corton
Hepatocellular proliferation in response to a peroxisome proliferator does not require TNF{alpha} signaling
Carcinogenesis, November 1, 2001; 22(11): 1843 - 1851.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Wang, E. Quail, N.-J. Hung, Y. Tan, H. Ye, and R. H. Costa
Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver
PNAS, September 25, 2001; 98(20): 11468 - 11473.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. A. Rudnick, D. H. Perlmutter, and L. J. Muglia
Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration
PNAS, July 5, 2001; (2001) 151217998.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. Wallenius, K. Wallenius, M. Hisaoka, J. Sandstedt, C. Ohlsson, M. Kopf, and J.-O. Jansson
Retarded Liver Growth in Interleukin-6-Deficient and Tumor Necrosis Factor Receptor-1-Deficient Mice
Endocrinology, July 1, 2001; 142(7): 2953 - 2960.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
P Starkel, L Lambotte, C Sempoux, C De Saeger, A Saliez, D Maiter, and Y Horsmans
After portal branch ligation in the rat, cellular proliferation in associated with selective induction of c-Ha-ras, p53, cyclin E, and Cdk2
Gut, July 1, 2001; 49(1): 119 - 130.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. G. Koniaris, T. Zimmers-Koniaris, E. C. Hsiao, K. Chavin, J. V. Sitzmann, and J. M. Farber
Cytokine-Responsive Gene-2/IFN-Inducible Protein-10 Expression in Multiple Models of Liver and Bile Duct Injury Suggests a Role in Tissue Regeneration
J. Immunol., July 1, 2001; 167(1): 399 - 406.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. PIBIRI, G. M. LEDDA-COLUMBANO, C. COSSU, G. SIMBULA, M. MENEGAZZI, H. SHINOZUKA, and A. COLUMBANO
Cyclin D1 is an early target in hepatocyte proliferation induced by thyroid hormone (T3)
FASEB J, April 1, 2001; 15(6): 1006 - 1013.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. J. D. Delhanty, C. D. Scott, S. Babu, and R. C. Baxter
Acid-labile subunit regulation during the early stages of liver regeneration: implications for glucoregulation
Am J Physiol Endocrinol Metab, February 1, 2001; 280(2): E287 - E295.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. I. Leu, M. A. S. Crissey, J. P. Leu, G. Ciliberto, and R. Taub
Interleukin-6-Induced STAT3 and AP-1 Amplify Hepatocyte Nuclear Factor 1-Mediated Transactivation of Hepatic Genes, an Adaptive Response to Liver Injury
Mol. Cell. Biol., January 15, 2001; 21(2): 414 - 424.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
T. C. Weglarz, J. L. Degen, and E. P. Sandgren
Hepatocyte Transplantation into Diseased Mouse Liver : Kinetics of Parenchymal Repopulation and Identification of the Proliferative Capacity of Tetraploid and Octaploid Hepatocytes
Am. J. Pathol., December 1, 2000; 157(6): 1963 - 1974.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
D. W. Kim, M. A. Sovak, G. Zanieski, G. Nonet, R. Romieu-Mourez, A. W. Lau, L. J. Hafer, P. Yaswen, M. Stampfer, A. E. Rogers, et al.
Activation of NF-{kappa}B/Rel occurs early during neoplastic transformation of mammary cells
Carcinogenesis, May 1, 2000; 21(5): 871 - 879.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. M. Reimold, A. Etkin, I. Clauss, A. Perkins, D. S. Friend, J. Zhang, H. F. Horton, A. Scott, S. H. Orkin, M. C. Byrne, et al.
An essential role in liver development for transcription factor XBP-1
Genes & Dev., January 15, 2000; 14(2): 152 - 157.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
R. M. Gallucci, P. P. Simeonova, W. Toriumi, and M. I. Luster
TNF-{alpha} Regulates Transforming Growth Factor-{alpha} Expression in Regenerating Murine Liver and Isolated Hepatocytes
J. Immunol., January 15, 2000; 164(2): 872 - 878.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
G. M. Ledda-Columbano, M. Pibiri, R. Loi, A. Perra, H. Shinozuka, and A. Columbano
Early Increase in Cyclin-D1 Expression and Accelerated Entry of Mouse Hepatocytes into S Phase after Administration of the Mitogen 1,4-Bis[2-(3,5-Dichloropyridyloxy)] Benzene
Am. J. Pathol., January 1, 2000; 156(1): 91 - 97.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. Ye, A. X. Holterman, K. W. Yoo, R. R. Franks, and R. H. Costa
Premature Expression of the Winged Helix Transcription Factor HFH-11B in Regenerating Mouse Liver Accelerates Hepatocyte Entry into S Phase
Mol. Cell. Biol., December 1, 1999; 19(12): 8570 - 8580.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. Talarmin, C. Rescan, S. Cariou, D. Glaise, G. Zanninelli, M. Bilodeau, P. Loyer, C. Guguen-Guillouzo, and G. Baffet
The Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Cascade Activation Is a Key Signalling Pathway Involved in the Regulation of G1 Phase Progression in Proliferating Hepatocytes
Mol. Cell. Biol., September 1, 1999; 19(9): 6003 - 6011.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
C SELDEN, M KHALIL, and H J F HODGSON
What keeps hepatocytes on the straight and narrow? Maintaining differentiated function in the liver
Gut, April 1, 1999; 44(4): 443 - 446.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Peng, K. Du, S. Ramirez, R. H. Diamond, and R. Taub
Mitogenic Up-regulation of the PRL-1 Protein-tyrosine Phosphatase Gene by Egr-1. Egr-1 ACTIVATION IS AN EARLY EVENT IN LIVER REGENERATION
J. Biol. Chem., February 19, 1999; 274(8): 4513 - 4520.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Du, J. I. Leu, Y. Peng, and R. Taub
Transcriptional Up-regulation of the Delayed Early Gene HRS/SRp40 during Liver Regeneration. INTERACTIONS AMONG YY1, GA-BINDING PROTEINS, AND MITOGENIC SIGNALS
J. Biol. Chem., December 25, 1998; 273(52): 35208 - 35215.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
G. Servillo, M. A. Della Fazia, and P. Sassone-Corsi
Transcription factor CREM coordinates the timing of hepatocyte proliferation in the regenerating liver
Genes & Dev., December 1, 1998; 12(23): 3639 - 3643.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
H. H. Cha, E. J. Cram, E. C. Wang, A. J. Huang, H. G. Kasler, and G. L. Firestone
Glucocorticoids Stimulate p21 Gene Expression by Targeting Multiple Transcriptional Elements within a Steroid Responsive Region of the p21waf1/cip1 Promoter in Rat Hepatoma Cells
J. Biol. Chem., January 23, 1998; 273(4): 1998 - 2007.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
P. Loser, G. S. Jennings, M. Strauss, and V. Sandig
Reactivation of the Previously Silenced Cytomegalovirus Major Immediate-Early Promoter in the Mouse Liver: Involvement of NFkappa B
J. Virol., January 1, 1998; 72(1): 180 - 190.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Zhou and M. T. Kuo
NF-kappa B-mediated Induction of mdr1b Expression by Insulin in Rat Hepatoma Cells
J. Biol. Chem., June 13, 1997; 272(24): 15174 - 15183.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
G. K. Michalopoulos and M. C. DeFrances
Liver Regeneration
Science, April 4, 1997; 276(5309): 60 - 66.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Yamada, I. Kirillova, J. J. Peschon, and N. Fausto
Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
PNAS, February 18, 1997; 94(4): 1441 - 1446.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
D. E. Cressman, L. E. Greenbaum, R. A. DeAngelis, G. Ciliberto, E. E. Furth, V. Poli, and R. Taub
Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Science, November 22, 1996; 274(5291): 1379 - 1383.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
A. L. Allan, C. Albanese, R. G. Pestell, and J. LaMarre
Activating Transcription Factor 3 Induces DNA Synthesis and Expression of Cyclin D1 in Hepatocytes
J. Biol. Chem., July 13, 2001; 276(29): 27272 - 27280.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. A. Rudnick, D. H. Perlmutter, and L. J. Muglia
Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration
PNAS, July 17, 2001; 98(15): 8885 - 8890.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by The Federation of American Societies for Experimental Biology.