FASEB J. Avanti Polar Lipids
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cereghini, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cereghini, S.

The FASEB Journal, Vol 10, 267-282, Copyright © 1996 by The Federation of American Societies for Experimental Biology

REVIEWS

Liver-enriched transcription factors and hepatocyte differentiation

S Cereghini
Hopital Necker Enfants Malades, Paris, France.

Liver-specific gene expression in adult hepatocytes relies on four families of evolutionary conserved transcription factors that are liver- enriched but not restricted to this tissue. These factors function in unique combinations, often synergistically, to stimulate cell-specific transcription. Each family is composed of several members displaying similar, if not identical, DNA recognition properties and sharing structural homology in their DNA binding domains. The homo- and heterodimerization between members of a particular transcription factor family adds an additional level of complexity in gene regulation. The consequences of inactivating different family members in the mouse by homologous recombination, together with recent studies of their regulation, suggest a model for liver differentiation involving a regulatory network rather than a completely hierarchical genetic circuitry. These studies also indicate that individual regulators appear to serve multiple developmental functions. Their possible role in the progression through different stages of hepatic cell commitment and differentiation is discussed.


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
A. Vandenbon and K. Nakai
Modeling tissue-specific structural patterns in human and mouse promoters
Nucleic Acids Res., October 22, 2009; (2009) gkp866v1.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J.-M. Servitja, M. Pignatelli, M. A. Maestro, C. Cardalda, S. F. Boj, J. Lozano, E. Blanco, A. Lafuente, M. I. McCarthy, L. Sumoy, et al.
Hnf1{alpha} (MODY3) Controls Tissue-Specific Transcriptional Programs and Exerts Opposed Effects on Cell Growth in Pancreatic Islets and Liver
Mol. Cell. Biol., June 1, 2009; 29(11): 2945 - 2959.
[Abstract] [Full Text] [PDF]

Home page
 Circ Cardiovasc GenetHome page
A. P. Reiner, M. D. Gross, C. S. Carlson, S. J. Bielinski, L. A. Lange, M. Fornage, N. S. Jenny, J. Walston, R. P. Tracy, O. D. Williams, et al.
Common Coding Variants of the HNF1A Gene Are Associated With Multiple Cardiovascular Risk Phenotypes in Community-Based Samples of Younger and Older European-American Adults: The Coronary Artery Risk Development in Young Adults Study and The Cardiovascular Health Study
Circ Cardiovasc Genet, June 1, 2009; 2(3): 244 - 254.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H.-T. Yu, M. Yu, C.-Y. Li, Y.-Q. Zhan, W.-X. Xu, Y.-H. Li, W. Li, Z.-D. Wang, C.-H. Ge, and X.-M. Yang
Specific Expression and Regulation of Hepassocin in the Liver and Down-regulation of the Correlation of HNF1{alpha} with Decreased Levels of Hepassocin in Human Hepatocellular Carcinoma
J. Biol. Chem., May 15, 2009; 284(20): 13335 - 13347.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. Klein, G. A. Kullak-Ublick, M. Wagner, M. Trauner, and J. J. Eloranta
Hepatocyte nuclear factor-4{alpha} and bile acids regulate human concentrative nucleoside transporter-1 gene expression
Am J Physiol Gastrointest Liver Physiol, April 1, 2009; 296(4): G936 - G947.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. Wang, C. Hu, R. Zhang, Y. Bao, X. Ma, J. Lu, W. Qin, X. Shao, J. Lu, J. Xu, et al.
Common Variants of Hepatocyte Nuclear Factor 1{beta} Are Associated With Type 2 Diabetes in a Chinese Population
Diabetes, April 1, 2009; 58(4): 1023 - 1027.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Imai, R. Kikuchi, H. Kusuhara, S. Yagi, K. Shiota, and Y. Sugiyama
Analysis of DNA Methylation and Histone Modification Profiles of Liver-Specific Transporters
Mol. Pharmacol., March 1, 2009; 75(3): 568 - 576.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. D. Wilson, N. L. Barbosa-Morais, D. Schmidt, C. M. Conboy, L. Vanes, V. L. J. Tybulewicz, E. M. C. Fisher, S. Tavare, and D. T. Odom
Species-Specific Transcription in Mice Carrying Human Chromosome 21
Science, October 17, 2008; 322(5900): 434 - 438.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
B. A. Benayoun, S. Caburet, A. Dipietromaria, M. Bailly-Bechet, F. Batista, M. Fellous, D. Vaiman, and R. A. Veitia
The identification and characterization of a FOXL2 response element provides insights into the pathogenesis of mutant alleles
Hum. Mol. Genet., October 15, 2008; 17(20): 3118 - 3127.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. Lokmane, C. Haumaitre, P. Garcia-Villalba, I. Anselme, S. Schneider-Maunoury, and S. Cereghini
Crucial role of vHNF1 in vertebrate hepatic specification
Development, August 15, 2008; 135(16): 2777 - 2786.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Aoki, T. Terada, M. Kajiwara, K. Ogasawara, I. Ikai, O. Ogawa, T. Katsura, and K.-i. Inui
Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation
Am J Physiol Renal Physiol, July 1, 2008; 295(1): F165 - F170.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L. W. Harries, J. M. Locke, B. Shields, N. A. Hanley, K. P. Hanley, A. Steele, P. R. Njolstad, S. Ellard, and A. T. Hattersley
The Diabetic Phenotype in HNF4A Mutation Carriers Is Moderated By the Expression of HNF4A Isoforms From the P1 Promoter During Fetal Development
Diabetes, June 1, 2008; 57(6): 1745 - 1752.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. Yu, J. Wang, W. Li, Y. Z. Yuan, C. Y. Li, X. H. Qian, W. X. Xu, Y. Q. Zhan, and X. M. Yang
Proteomic screen defines the hepatocyte nuclear factor 1{alpha}-binding partners and identifies HMGB1 as a new cofactor of HNF1{alpha}
Nucleic Acids Res., March 27, 2008; 36(4): 1209 - 1219.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
M. J. Liguori, E. A.G. Blomme, and J. F. Waring
Trovafloxacin-Induced Gene Expression Changes in Liver-Derived in Vitro Systems: Comparison of Primary Human Hepatocytes to HepG2 Cells
Drug Metab. Dispos., February 1, 2008; 36(2): 223 - 233.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Jonckheere, A. Vincent, M. Perrais, M.-P. Ducourouble, A. K.-v. Male, J.-P. Aubert, P. Pigny, K. L. Carraway, J.-N. Freund, I. B. Renes, et al.
The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells
J. Biol. Chem., August 3, 2007; 282(31): 22638 - 22650.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Cavadini, S. Petrzilka, P. Kohler, C. Jud, I. Tobler, T. Birchler, and A. Fontana
From the Cover: TNF-{alpha} suppresses the expression of clock genes by interfering with E-box-mediated transcription
PNAS, July 31, 2007; 104(31): 12843 - 12848.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Jain, Y. Li, S. Patil, and A. Kumar
HNF-1{alpha} plays an important role in IL-6-induced expression of the human angiotensinogen gene
Am J Physiol Cell Physiol, July 1, 2007; 293(1): C401 - C410.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
P. Hatzis, I. Kyrmizi, and I. Talianidis
Mitogen-Activated Protein Kinase-Mediated Disruption of Enhancer-Promoter Communication Inhibits Hepatocyte Nuclear Factor 4{alpha} Expression.
Mol. Cell. Biol., October 1, 2006; 26(19): 7017 - 7029.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
I. Kyrmizi, P. Hatzis, N. Katrakili, F. Tronche, F. J. Gonzalez, and I. Talianidis
Plasticity and expanding complexity of the hepatic transcription factor network during liver development.
Genes & Dev., August 15, 2006; 20(16): 2293 - 2305.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J.-B. Beaudry, C. E. Pierreux, G. P. Hayhurst, N. Plumb-Rudewiez, M. C. Weiss, G. G. Rousseau, and F. P. Lemaigre
Threshold Levels of Hepatocyte Nuclear Factor 6 (HNF-6) Acting in Synergy with HNF-4 and PGC-1{alpha} Are Required for Time-Specific Gene Expression during Liver Development.
Mol. Cell. Biol., August 1, 2006; 26(16): 6037 - 6046.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-S. Su, T.-F. Tsai, H.-M. Chang, K.-M. Chao, T.-S. Su, and S.-F. Tsai
Distant HNF1 Site as a Master Control for the Human Class I Alcohol Dehydrogenase Gene Expression
J. Biol. Chem., July 21, 2006; 281(29): 19809 - 19821.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
H. J Welters, S. Senkel, L. Klein-Hitpass, S. Erdmann, H. Thomas, L. W Harries, E. R Pearson, C. Bingham, A. T Hattersley, G. U Ryffel, et al.
Conditional expression of hepatocyte nuclear factor-1{beta}, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic {beta}-cells.
J. Endocrinol., July 1, 2006; 190(1): 171 - 181.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
L. Romero, L. Ng, and G. M. Kirby
Chemical Inducers of Rodent Glutathione S-Transferases Down-Regulate Human GSTA1 Transcription through a Mechanism Involving Variant Hepatic Nuclear Factor 1-C
Mol. Pharmacol., July 1, 2006; 70(1): 277 - 286.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Saborowski, G. A. Kullak-Ublick, and J. J. Eloranta
The Human Organic Cation Transporter-1 Gene Is Transactivated by Hepatocyte Nuclear Factor-4{alpha}
J. Pharmacol. Exp. Ther., May 1, 2006; 317(2): 778 - 785.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-i. Satoh, T. Noaki, T. Ishigure, S. Osada, M. Imagawa, N. Miura, K. Yamada, and T. Noguchi
Nuclear Factor 1 Family Members Interact with Hepatocyte Nuclear Factor 1{alpha} to Synergistically Activate L-type Pyruvate Kinase Gene Transcription
J. Biol. Chem., December 2, 2005; 280(48): 39827 - 39834.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. E. Rubins, J. R. Friedman, P. P. Le, L. Zhang, J. Brestelli, and K. H. Kaestner
Transcriptional Networks in the Liver: Hepatocyte Nuclear Factor 6 Function Is Largely Independent of Foxa2
Mol. Cell. Biol., August 15, 2005; 25(16): 7069 - 7077.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
M. E. Wyde, S. E. Kirwan, F. Zhang, A. Laughter, H. B. Hoffman, E. Bartolucci-Page, K. W. Gaido, B. Yan, and L. You
Di-n-Butyl Phthalate Activates Constitutive Androstane Receptor and Pregnane X Receptor and Enhances the Expression of Steroid-Metabolizing Enzymes in the Liver of Rat Fetuses
Toxicol. Sci., August 1, 2005; 86(2): 281 - 290.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. W. Abrams and D. J. Andrew
CrebA regulates secretory activity in the Drosophila salivary gland and epidermis
Development, June 15, 2005; 132(12): 2743 - 2758.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
K. Popowski, J. J. Eloranta, M. Saborowski, M. Fried, P. J. Meier, and G. A. Kullak-Ublick
The Human Organic Anion Transporter 2 Gene Is Transactivated by Hepatocyte Nuclear Factor-4{alpha} and Suppressed by Bile Acids
Mol. Pharmacol., May 1, 2005; 67(5): 1629 - 1638.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. Rebouissou, V. Vasiliu, C. Thomas, C. Bellanne-Chantelot, H. Bui, Y. Chretien, J. Timsit, C. Rosty, P. Laurent-Puig, D. Chauveau, et al.
Germline hepatocyte nuclear factor 1{alpha} and 1{beta} mutations in renal cell carcinomas
Hum. Mol. Genet., March 1, 2005; 14(5): 603 - 614.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
S Eleswarapu and H Jiang
Growth hormone regulates the expression of hepatocyte nuclear factor-3 gamma and other liver-enriched transcription factors in the bovine liver
J. Endocrinol., January 1, 2005; 184(1): 95 - 105.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
O. Barbier, H. Girard, Y. Inoue, H. Duez, L. Villeneuve, A. Kamiya, J.-C. Fruchart, C. Guillemette, F. J. Gonzalez, and B. Staels
Hepatic Expression of the UGT1A9 Gene Is Governed by Hepatocyte Nuclear Factor 4{alpha}
Mol. Pharmacol., January 1, 2005; 67(1): 241 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
E. Barbacci, A. Chalkiadaki, C. Masdeu, C. Haumaitre, L. Lokmane, C. Loirat, S. Cloarec, I. Talianidis, C. Bellanne-Chantelot, and S. Cereghini
HNF1{beta}/TCF2 mutations impair transactivation potential through altered co-regulator recruitment
Hum. Mol. Genet., December 15, 2004; 13(24): 3139 - 3149.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J.-Y. Kim, H.-J. Kim, K. T. Kim, Y.-Y. Park, H.-A Seong, K. C. Park, I.-K. Lee, H. Ha, M. Shong, S. C. Park, et al.
Orphan Nuclear Receptor Small Heterodimer Partner Represses Hepatocyte Nuclear Factor 3/Foxa Transactivation via Inhibition of Its DNA Binding
Mol. Endocrinol., December 1, 2004; 18(12): 2880 - 2894.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
E. Fischer, L. Gresh, A. Reimann, and M. Pontoglio
Cystic kidney diseases: learning from animal models
Nephrol. Dial. Transplant., November 1, 2004; 19(11): 2700 - 2702.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Briancon, A. Bailly, F. Clotman, P. Jacquemin, F. P. Lemaigre, and M. C. Weiss
Expression of the {alpha}7 Isoform of Hepatocyte Nuclear Factor (HNF) 4 Is Activated by HNF6/OC-2 and HNF1 and Repressed by HNF4{alpha}1 in the Liver
J. Biol. Chem., August 6, 2004; 279(32): 33398 - 33408.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Halmos, D. S. Basseres, S. Monti, F. D'Alo, T. Dayaram, K. Ferenczi, B. J. Wouters, C. S. Huettner, T. R. Golub, and D. G. Tenen
A Transcriptional Profiling Study of CCAAT/Enhancer Binding Protein Targets Identifies Hepatocyte Nuclear Factor 3{beta} as a Novel Tumor Suppressor in Lung Cancer
Cancer Res., June 15, 2004; 64(12): 4137 - 4147.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Yorifuji, K. Kurokawa, M. Mamada, T. Imai, M. Kawai, Y. Nishi, S. Shishido, Y. Hasegawa, and T. Nakahata
Neonatal Diabetes Mellitus and Neonatal Polycystic, Dysplastic Kidneys: Phenotypically Discordant Recurrence of a Mutation in the Hepatocyte Nuclear Factor-1{beta} Gene Due to Germline Mosaicism
J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2905 - 2908.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. Eeckhoute, P. Formstecher, and B. Laine
Hepatocyte Nuclear Factor 4{alpha} enhances the Hepatocyte Nuclear Factor 1{alpha}-mediated activation of transcription
Nucleic Acids Res., May 11, 2004; 32(8): 2586 - 2593.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
D. Jung, B. Hagenbuch, M. Fried, P. J. Meier, and G. A. Kullak-Ublick
Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene
Am J Physiol Gastrointest Liver Physiol, May 1, 2004; 286(5): G752 - G761.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. B. Koukouritaki, J. R. Manro, S. A. Marsh, J. C. Stevens, A. E. Rettie, D. G. McCarver, and R. N. Hines
Developmental Expression of Human Hepatic CYP2C9 and CYP2C19
J. Pharmacol. Exp. Ther., March 1, 2004; 308(3): 965 - 974.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. A. Maestro, S. F. Boj, R. F. Luco, C. E. Pierreux, J. Cabedo, J. M. Servitja, M. S. German, G. G. Rousseau, F. P. Lemaigre, and J. Ferrer
Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas
Hum. Mol. Genet., December 15, 2003; 12(24): 3307 - 3314.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Haumaitre, M. Reber, and S. Cereghini
Functions of HNF1 Family Members in Differentiation of the Visceral Endoderm Cell Lineage
J. Biol. Chem., October 17, 2003; 278(42): 40933 - 40942.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
F. Yadetie, A. Laegreid, I. Bakke, W. Kusnierczyk, J. Komorowski, H. L. Waldum, and A. K. Sandvik
Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-{alpha} agonist ciprofibrate
Physiol Genomics, September 29, 2003; 15(1): 9 - 19.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. Gautier-Stein, C. Domon-Dell, A. Calon, I. Bady, J.-N. Freund, G. Mithieux, and F. Rajas
Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2
Nucleic Acids Res., September 15, 2003; 31(18): 5238 - 5246.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Bohn, H. Thomas, G. Turan, S. Ellard, C. Bingham, A. T. Hattersley, and G. U. Ryffel
Distinct Molecular and Morphogenetic Properties of Mutations in the Human HNF1{beta} Gene That Lead to Defective Kidney Development
J. Am. Soc. Nephrol., August 1, 2003; 14(8): 2033 - 2041.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C. Rodriguez-Antona, R. Bort, R. Jover, N. Tindberg, M. Ingelman-Sundberg, M. J. Gomez-Lechon, and J. V. Castell
Transcriptional Regulation of Human CYP3A4 Basal Expression by CCAAT Enhancer-Binding Protein alpha and Hepatocyte Nuclear Factor-3gamma
Mol. Pharmacol., May 1, 2003; 63(5): 1180 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. K. Bosserhoff, M. Moser, J. Scholmerich, R. Buettner, and C. Hellerbrand
Specific Expression and Regulation of the New Melanoma Inhibitory Activity-related Gene MIA2 in Hepatocytes
J. Biol. Chem., April 18, 2003; 278(17): 15225 - 15231.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. Trauner and J. L. Boyer
Bile Salt Transporters: Molecular Characterization, Function, and Regulation
Physiol Rev, April 1, 2003; 83(2): 633 - 671.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Clotman, V. J. Lannoy, M. Reber, S. Cereghini, D. Cassiman, P. Jacquemin, T. Roskams, G. G. Rousseau, and F. P. Lemaigre
The onecut transcription factor HNF6 is required for normal development of the biliary tract
Development, March 6, 2003; 129(8): 1819 - 1828.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Coffinier, L. Gresh, L. Fiette, F. Tronche, G. Schutz, C. Babinet, M. Pontoglio, M. Yaniv, and J. Barra
Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1{beta}
Development, March 6, 2003; 129(8): 1829 - 1838.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Jung, M. Fried, and G. A. Kullak-Ublick
Human Apical Sodium-dependent Bile Salt Transporter Gene (SLC10A2) Is Regulated by the Peroxisome Proliferator-activated Receptor alpha
J. Biol. Chem., August 16, 2002; 277(34): 30559 - 30566.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. H. Bayle, F. Randazzo, G. Johnen, S. Kaufman, A. Nagy, J. Rossant, and G. R. Crabtree
Hyperphenylalaninemia and Impaired Glucose Tolerance in Mice Lacking the Bifunctional DCoH Gene
J. Biol. Chem., August 2, 2002; 277(32): 28884 - 28891.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Inoue, G. P. Hayhurst, J. Inoue, M. Mori, and F. J. Gonzalez
Defective Ureagenesis in Mice Carrying a Liver-specific Disruption of Hepatocyte Nuclear Factor 4alpha (HNF4alpha ). HNF4alpha REGULATES ORNITHINE TRANSCARBAMYLASE IN VIVO
J. Biol. Chem., July 5, 2002; 277(28): 25257 - 25265.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Sakaguchi, X. Gu, H. M. Golden, E. Suh, D. B. Rhoads, and H.-C. Reinecker
Cloning of the Human Claudin-2 5'-Flanking Region Revealed a TATA-less Promoter with Conserved Binding Sites in Mouse and Human for Caudal-related Homeodomain Proteins and Hepatocyte Nuclear Factor-1alpha
J. Biol. Chem., June 7, 2002; 277(24): 21361 - 21370.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Pastier, J.-M. Lacorte, J. Chambaz, P. Cardot, and A. Ribeiro
Two Initiator-like Elements Are Required for the Combined Activation of the Human Apolipoprotein C-III Promoter by Upstream Stimulatory Factor and Hepatic Nuclear Factor-4
J. Biol. Chem., April 19, 2002; 277(17): 15199 - 15206.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Naiki, M. Nagaki, Y. Shidoji, H. Kojima, M. Imose, T. Kato, N. Ohishi, K. Yagi, and H. Moriwaki
Analysis of Gene Expression Profile Induced by Hepatocyte Nuclear Factor 4alpha in Hepatoma Cells Using an Oligonucleotide Microarray
J. Biol. Chem., April 12, 2002; 277(16): 14011 - 14019.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. L. Triggs-Raine, R. D. Kirkpatrick, S. L. Kelly, L. D. Norquay, P. A. Cattini, K. Yamagata, A. J. G. Hanley, B. Zinman, S. B. Harris, P. H. Barrett, et al.
HNF-1alpha G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community
PNAS, April 2, 2002; 99(7): 4614 - 4619.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Hu and D. H. Perlmutter
Cell-specific involvement of HNF-1beta in alpha 1-antitrypsin gene expression in human respiratory epithelial cells
Am J Physiol Lung Cell Mol Physiol, April 1, 2002; 282(4): L757 - L765.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
D. G. McCarver and R. N. Hines
The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms
J. Pharmacol. Exp. Ther., February 1, 2002; 300(2): 361 - 366.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Gerrish, M. A. Cissell, and R. Stein
The Role of Hepatic Nuclear Factor 1alpha and PDX-1 in Transcriptional Regulation of the pdx-1 Gene
J. Biol. Chem., December 14, 2001; 276(51): 47775 - 47784.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Z. Luo and R. N. Hines
Regulation of Flavin-Containing Monooxygenase 1 Expression by Ying Yang 1 and Hepatic Nuclear Factors 1 and 4
Mol. Pharmacol., December 1, 2001; 60(6): 1421 - 1430.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Shen, L. M. Scearce, J. E. Brestelli, N. J. Sund, and K. H. Kaestner
Foxa3 (Hepatocyte Nuclear Factor 3gamma ) Is Required for the Regulation of Hepatic GLUT2 Expression and the Maintenance of Glucose Homeostasis during a Prolonged Fast
J. Biol. Chem., November 9, 2001; 276(46): 42812 - 42817.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
S. S. Fajans, G. I. Bell, and K. S. Polonsky
Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young
N. Engl. J. Med., September 27, 2001; 345(13): 971 - 980.
[Full Text] [PDF]

Home page
 Hum Mol GenetHome page
H. Thomas, K. Jaschkowitz, M. Bulman, T. M. Frayling, S. M.S. Mitchell, S. Roosen, A. Lingott-Frieg, C. J. Tack, S. Ellard, G. U. Ryffel, et al.
A distant upstream promoter of the HNF-4{alpha} gene connects the transcription factors involved in maturity-onset diabetes of the young
Hum. Mol. Genet., September 1, 2001; 10(19): 2089 - 2097.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. Bailly, M. E. Torres-Padilla, A. P. Tinel, and M. C. Weiss
An enhancer element 6 kb upstream of the mouse HNF4{alpha}1 promoter is activated by glucocorticoids and liver-enriched transcription factors
Nucleic Acids Res., September 1, 2001; 29(17): 3495 - 3505.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. Viollet, M. Yaniv, and M. Pontoglio
Embryonic but Not Postnatal Reexpression of Hepatocyte Nuclear Factor 1{alpha} (HNF1{alpha}) Can Reactivate the Silent Phenylalanine Hydroxylase Gene in HNF1{alpha}-Deficient Hepatocytes
Mol. Cell. Biol., June 1, 2001; 21(11): 3662 - 3670.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
E. P. v. Strandmann, S. Senkel, G. Ryffel, and U. R. Hengge
Dimerization Co-Factor of Hepatocyte Nuclear Factor 1/Pterin-4{{alpha}}-Carbinolamine Dehydratase Is Necessary for Pigmentation in Xenopus and Overexpressed in Primary Human Melanoma Lesions
Am. J. Pathol., June 1, 2001; 158(6): 2021 - 2029.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. H. Costa, V. V. Kalinichenko, and L. Lim
Transcription factors in mouse lung development and function
Am J Physiol Lung Cell Mol Physiol, May 1, 2001; 280(5): L823 - L838.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
R. N. Hines, Z. Luo, T. Cresteil, X. Ding, R. A. Prough, J. L. Fitzpatrick, S. L. Ripp, K. C. Falkner, N.-L. Ge, A. Levine, et al.
Molecular Regulation of Genes Encoding Xenobiotic-Metabolizing Enzymes: Mechanisms Involving Endogenous Factors
Drug Metab. Dispos., April 13, 2001; 29(5): 623 - 633.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
L. Xu, L. Hui, S. Wang, J. Gong, Y. Jin, Y. Wang, Y. Ji, X. Wu, Z. Han, and G. Hu
Expression Profiling Suggested a Regulatory Role of Liver-enriched Transcription Factors in Human Hepatocellular Carcinoma
Cancer Res., April 1, 2001; 61(7): 3176 - 3181.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
G. P. Hayhurst, Y.-H. Lee, G. Lambert, J. M. Ward, and F. J. Gonzalez
Hepatocyte Nuclear Factor 4{alpha} (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis
Mol. Cell. Biol., February 15, 2001; 21(4): 1393 - 1403.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
J. I. Leu, M. A. S. Crissey, J. P. Leu, G. Ciliberto, and R. Taub
Interleukin-6-Induced STAT3 and AP-1 Amplify Hepatocyte Nuclear Factor 1-Mediated Transactivation of Hepatic Genes, an Adaptive Response to Liver Injury
Mol. Cell. Biol., January 15, 2001; 21(2): 414 - 424.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
F. M. Rausa, Y. Tan, H. Zhou, K. W. Yoo, D. B. Stolz, S. C. Watkins, R. R. Franks, T. G. Unterman, and R. H. Costa
Elevated Levels of Hepatocyte Nuclear Factor 3beta in Mouse Hepatocytes Influence Expression of Genes Involved in Bile Acid and Glucose Homeostasis
Mol. Cell. Biol., November 1, 2000; 20(21): 8264 - 8282.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
N. J. Sund, S.-L. Ang, S. D. Sackett, W. Shen, N. Daigle, M. A. Magnuson, and K. H. Kaestner
Hepatocyte Nuclear Factor 3beta (Foxa2) Is Dispensable for Maintaining the Differentiated State of the Adult Hepatocyte
Mol. Cell. Biol., July 15, 2000; 20(14): 5175 - 5183.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Santamarina-Fojo, K. Peterson, C. Knapper, Y. Qiu, L. Freeman, J.-F. Cheng, J. Osorio, A. Remaley, X.-P. Yang, C. Haudenschild, et al.
Complete genomic sequence of the human ABCA1 gene: Analysis of the human and mouse ATP-binding cassette A promoter
PNAS, July 5, 2000; 97(14): 7987 - 7992.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Rastegar, G. G. Rousseau, and F. P. Lemaigre
CCAAT/Enhancer-Binding Protein-{alpha} Is a Component of the Growth Hormone-Regulated Network of Liver Transcription Factors
Endocrinology, May 1, 2000; 141(5): 1686 - 1692.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. Li, G. Ning, and S. A. Duncan
Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha
Genes & Dev., February 15, 2000; 14(4): 464 - 474.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
O. Lahuna, M. Rastegar, D. Maiter, J.-P. Thissen, F. P. Lemaigre, and G. G. Rousseau
Involvement of STAT5 (Signal Transducer and Activator of Transcription 5) and HNF-4 (Hepatocyte Nuclear Factor 4) in the Transcriptional Control of the hnf6 Gene by Growth Hormone
Mol. Endocrinol., February 1, 2000; 14(2): 285 - 294.
[Abstract] [Full Text]

Home page
 Nucleic Acids ResHome page
J. Lausen, H. Thomas, I. Lemm, M. Bulman, M. Borgschulze, A. Lingott, A. T. Hattersley, and G. U. Ryffel
Naturally occurring mutations in the human HNF4{alpha} gene impair the function of the transcription factor to a varying degree
Nucleic Acids Res., January 15, 2000; 28(2): 430 - 437.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. A. Hegele, H. Cao, S. B. Harris, A. J. G. Hanley, B. Zinman, and P. W. Connelly
The Private Hepatocyte Nuclear Factor-1{alpha} G319S Variant Is Associated With Plasma Lipoprotein Variation in Canadian Oji-Cree
Arterioscler Thromb Vasc Biol, January 1, 2000; 20(1): 217 - 222.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. N. BHATIA, U. J. BALIS, M. L. YARMUSH, and M. TONER
Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells
FASEB J, November 1, 1999; 13(14): 1883 - 1900.
[Abstract] [Full Text]

Home page
 Mol. Pharmacol.Home page
P. Bernard, H. Goudonnet, Y. Artur, B. Desvergne, and W. Wahli
Activation of the Mouse TATA-less and Human TATA-Containing UDP-Glucuronosyltransferase 1A1 Promoters by Hepatocyte Nuclear Factor 1
Mol. Pharmacol., September 1, 1999; 56(3): 526 - 536.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Rollini and R. E. K. Fournier
The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1
PNAS, August 31, 1999; 96(18): 10308 - 10313.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. J. Crowe, L. Sang, K. K. Li, K. C. Lee, B. T. Spear, and M. C. Barton
Hepatocyte Nuclear Factor 3 Relieves Chromatin-mediated Repression of the alpha -Fetoprotein Gene
J. Biol. Chem., August 27, 1999; 274(35): 25113 - 25120.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Yang, L.-W. Dong, C. Tang, and M.-S. Liu
Transcriptional and posttranscriptional regulation of beta 2-adrenergic receptor gene in rat liver during sepsis
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R132 - R139.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
C SELDEN, M KHALIL, and H J F HODGSON
What keeps hepatocytes on the straight and narrow? Maintaining differentiated function in the liver
Gut, April 1, 1999; 44(4): 443 - 446.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. A. Hegele, H. Cao, S. B. Harris, A. J. G. Hanley, and B. Zinman
The Hepatic Nuclear Factor-1{alpha} G319S Variant Is Associated with Early-Onset Type 2 Diabetes in Canadian Oji-Cree
J. Clin. Endocrinol. Metab., March 1, 1999; 84(3): 1077 - 1082.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
K. H. Kaestner, J. Katz, Y. Liu, D. J. Drucker, and G. Schütz
Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo
Genes & Dev., February 15, 1999; 13(4): 495 - 504.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
P. Jacquemin, V. J. Lannoy, G. G. Rousseau, and F. P. Lemaigre
OC-2, a Novel Mammalian Member of the ONECUT Class of Homeodomain Transcription Factors Whose Function in Liver Partially Overlaps with That of Hepatocyte Nuclear Factor-6
J. Biol. Chem., January 29, 1999; 274(5): 2665 - 2671.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E Barbacci, M Reber, M. Ott, C Breillat, F Huetz, and S Cereghini
Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification
Development, January 11, 1999; 126(21): 4795 - 4805.
[Abstract] [PDF]

Home page
 Drug Metab. Dispos.Home page
E. T. Morgan, M. B. Sewer, H. Iber, F. J. Gonzalez, Y.-H. Lee, R. H. Tukey, S. Okino, T. Vu, Y.-H. Chen, J. S. Sidhu, et al.
Physiological and Pathophysiological Regulation of Cytochrome P450
Drug Metab. Dispos., December 1, 1998; 26(12): 1232 - 1240.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. A. Urhammer, T. Hansen, C. T. Ekstrøm, H. Eiberg, and O. Pedersen
The Ala/Val98 Polymorphism of the Hepatocyte Nuclear Factor-1{alpha} Gene Contributes to the Interindividual Variation in Serum C-Peptide Response during an Oral Glucose Tolerance Test: Evidence from Studies of 231 Glucose-Tolerant First Degree Relatives of Type 2 Diabetic Probands
J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4506 - 4509.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
D. M. Dean, R. R. Berger, and M. M. Sanders
A Winged-Helix Family Member Is Involved in a Steroid Hormone-Triggered Regulatory Circuit
Endocrinology, December 1, 1998; 139(12): 4967 - 4975.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
F. M. Spagnoli, L. Amicone, M. Tripodi, and M. C. Weiss
Identification of a Bipotential Precursor Cell in Hepatic Cell Lines Derived from Transgenic Mice Expressing Cyto-Met in the Liver
J. Cell Biol., November 16, 1998; 143(4): 1101 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Z. Kapitskaya, N. T. Dittmer, K. W. Deitsch, W.-L. Cho, D. G. Taylor, T. Leff, and A. S. Raikhel
Three Isoforms of a Hepatocyte Nuclear Factor-4 Transcription Factor with Tissue- and Stage-specific Expression in the Adult Mosquito
J. Biol. Chem., November 6, 1998; 273(45): 29801 - 29810.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-H. Song, K. Ray, S. A. Liebhaber, and N. E. Cooke
Vitamin D-binding Protein Gene Transcription Is Regulated by the Relative Abundance of Hepatocyte Nuclear Factors 1alpha and 1beta
J. Biol. Chem., October 23, 1998; 273(43): 28408 - 28418.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
S. A. Duncan, M. A. Navas, D. Dufort, J. Rossant, and M. Stoffel
Regulation of a Transcription Factor Network Required for Differentiation and Metabolism
Science, July 31, 1998; 281(5377): 692 - 695.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by The Federation of American Societies for Experimental Biology.