FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kornblihtt, A. R.
Right arrow Articles by Muro, A. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kornblihtt, A. R.
Right arrow Articles by Muro, A. F.

The FASEB Journal, Vol 10, 248-257, Copyright © 1996 by The Federation of American Societies for Experimental Biology

REVIEWS

The fibronectin gene as a model for splicing and transcription studies

AR Kornblihtt, CG Pesce, CR Alonso, P Cramer, A Srebrow, S Werbajh and AF Muro
Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI), Buenos Aires, Argentina.

The fibronectin (FN) gene has become paradigmatic to illustrate genome evolution by exon shuffling, generation of protein diversity by alternative mRNA splicing, and topological coordination between transcription and splicing. Alternative splicing in three sites of the primary transcript gives rise to multiple FN polypeptides. This process is cell type-, development- and age-regulated. The different FN variants seem to play specific roles in FN dimer secretion, blood clotting, adhesion to lymphoid cells, skin wound healing, atherosclerosis, and liver fibrosis. This review focuses on function assignment to the alternatively spliced segments, as well as on the external signals and cis-acting sequences that control the mechanisms of alternative splicing. We also discuss FN transcriptional regulation in response to viral transformation, growth factors, and cyclic AMP in the light of promoter architecture and its interaction with specific transcription factors. The relevance of FN RNA "tracks" as assembly lines of coordinated transcription and RNA processing is also addressed.


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
F. Castelletti, R. Donadelli, F. Banterla, F. Hildebrandt, P. F. Zipfel, E. Bresin, E. Otto, C. Skerka, A. Renieri, M. Todeschini, et al.
Mutations in FN1 cause glomerulopathy with fibronectin deposits
PNAS, February 19, 2008; 105(7): 2538 - 2543.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. K. Chauhan, J. Kisucka, M. R. Cozzi, M. T. Walsh, F. A. Moretti, M. Battiston, M. Mazzucato, L. De Marco, F. E. Baralle, D. D. Wagner, et al.
Prothrombotic Effects of Fibronectin Isoforms Containing the EDA Domain
Arterioscler. Thromb. Vasc. Biol., February 1, 2008; 28(2): 296 - 301.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
S. Takahashi, M. Leiss, M. Moser, T. Ohashi, T. Kitao, D. Heckmann, A. Pfeifer, H. Kessler, J. Takagi, H. P. Erickson, et al.
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly
J. Cell Biol., October 3, 2007; 178(1): 167 - 178.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. A. Moretti, A. K. Chauhan, A. Iaconcig, F. Porro, F. E. Baralle, and A. F. Muro
A Major Fraction of Fibronectin Present in the Extracellular Matrix of Tissues Is Plasma-derived
J. Biol. Chem., September 21, 2007; 282(38): 28057 - 28062.
[Abstract] [Full Text] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
H.-S. Li-Korotky, P. A. Hebda, C.-Y. Lo, and J. E. Dohar
Age-Dependent Differential Expression of Fibronectin Variants in Skin and Airway Mucosal Wounds
Arch Otolaryngol Head Neck Surg, September 1, 2007; 133(9): 919 - 924.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Beer and L. Pedersen
Matrix Fibronectin Binds Gammaretrovirus and Assists in Entry: New Light on Viral Infections
J. Virol., August 1, 2007; 81(15): 8247 - 8257.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
B. Marom, M. A. Rahat, N. Lahat, L. Weiss-Cerem, A. Kinarty, and H. Bitterman
Native and fragmented fibronectin oppositely modulate monocyte secretion of MMP-9
J. Leukoc. Biol., June 1, 2007; 81(6): 1466 - 1476.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Papp, M. P. Fadel, H. Kim, C. A. McCulloch, and M. Opas
Calreticulin Affects Fibronectin-based Cell-Substratum Adhesion via the Regulation of c-Src Activity
J. Biol. Chem., June 1, 2007; 282(22): 16585 - 16598.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Ray, E. C. Osmundson, and H. Kiyokawa
Constitutive and UV-induced Fibronectin Degradation Is a Ubiquitination-dependent Process Controlled by beta-TrCP
J. Biol. Chem., August 11, 2006; 281(32): 23060 - 23065.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
D. L. Fleenor, A. R. Shepard, P. E. Hellberg, N. Jacobson, I.-H. Pang, and A. F. Clark
TGF{beta}2-Induced Changes in Human Trabecular Meshwork: Implications for Intraocular Pressure
Invest. Ophthalmol. Vis. Sci., January 1, 2006; 47(1): 226 - 234.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
H.E. van Beurden, J.W. Von den Hoff, R. Torensma, J.C. Maltha, and A.M. Kuijpers-Jagtman
Myofibroblasts in Palatal Wound Healing: Prospects for the Reduction of Wound Contraction after Cleft Palate Repair
J. Dent. Res., October 1, 2005; 84(10): 871 - 880.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Pelisch, M. Blaustein, A. R. Kornblihtt, and A. Srebrow
Cross-talk between Signaling Pathways Regulates Alternative Splicing: A NOVEL ROLE FOR JNK
J. Biol. Chem., July 8, 2005; 280(27): 25461 - 25469.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M.-L. Chang, J.-C. Chen, C. R. Alonso, A. R. Kornblihtt, and D. M. Bissell
Regulation of fibronectin splicing in sinusoidal endothelial cells from normal or injured liver
PNAS, December 28, 2004; 101(52): 18093 - 18098.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Blaustein, F. Pelisch, O. A. Coso, M. J. Bissell, A. R. Kornblihtt, and A. Srebrow
Mammary Epithelial-Mesenchymal Interaction Regulates Fibronectin Alternative Splicing via Phosphatidylinositol 3-Kinase
J. Biol. Chem., May 14, 2004; 279(20): 21029 - 21037.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
K Probst, R Fijnheer, P Schellekens, and A Rothova
Intraocular and plasma levels of cellular fibronectin in patients with uveitis and diabetes mellitus
Br. J. Ophthalmol., May 1, 2004; 88(5): 667 - 672.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. L. Schor, I. R. Ellis, S. J. Jones, R. Baillie, K. Seneviratne, J. Clausen, K. Motegi, B. Vojtesek, K. Kankova, E. Furrie, et al.
Migration-Stimulating Factor: A Genetically Truncated Onco-Fetal Fibronectin Isoform Expressed by Carcinoma and Tumor-Associated Stromal Cells
Cancer Res., December 15, 2003; 63(24): 8827 - 8836.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. Filenius, T. Tervo, and I. Virtanen
Production of Fibronectin and Tenascin Isoforms and Their Role in the Adhesion of Human Immortalized Corneal Epithelial Cells
Invest. Ophthalmol. Vis. Sci., August 1, 2003; 44(8): 3317 - 3325.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
A. F. Muro, A. K. Chauhan, S. Gajovic, A. Iaconcig, F. Porro, G. Stanta, and F. E. Baralle
Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan
J. Cell Biol., July 7, 2003; 162(1): 149 - 160.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. A. Kunz-Schughart, S. Wenninger, T. Neumeier, P. Seidl, and R. Knuechel
Three-dimensional tissue structure affects sensitivity of fibroblasts to TGF-beta 1
Am J Physiol Cell Physiol, January 1, 2003; 284(1): C209 - C219.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Kadener, J. P. Fededa, M. Rosbash, and A. R. Kornblihtt
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
PNAS, June 11, 2002; 99(12): 8185 - 8190.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Kalbfuss, S. A. Mabon, and T. Misteli
Correction of Alternative Splicing of Tau in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17
J. Biol. Chem., November 9, 2001; 276(46): 42986 - 42993.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. Soboloff, H. Sasaki, and B.K. Tsang
Follicular Stage-Dependent Tumor Necrosis Factor {alpha}-Induced Hen Granulosa Cell Integrin Production and Survival in the Presence of Transforming Growth Factor {alpha} In Vitro
Biol Reprod, August 1, 2001; 65(2): 477 - 487.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
S. D.J.M. Kanters, J.-D. Banga, A. Algra, R. C.J.M. Frijns, J. J. Beutler, and R. Fijnheer
Plasma Levels of Cellular Fibronectin in Diabetes
Diabetes Care, February 1, 2001; 24(2): 323 - 327.
[Abstract] [Full Text]

Home page
 Nucleic Acids ResHome page
W. van der Houven van Oordt, K. Newton, G. R. Screaton, and J. F. Caceres
Role of SR protein modular domains in alternative splicing specificity in vivo
Nucleic Acids Res., December 15, 2000; 28(24): 4822 - 4831.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K.-S. Lee, H.-J. Kim, Q.-L. Li, X.-Z. Chi, C. Ueta, T. Komori, J. M. Wozney, E.-G. Kim, J.-Y. Choi, H.-M. Ryoo, et al.
Runx2 Is a Common Target of Transforming Growth Factor beta 1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12
Mol. Cell. Biol., December 1, 2000; 20(23): 8783 - 8792.
[Abstract] [Full Text]

Home page
 BloodHome page
A. Condino-Neto and P. E. Newburger
Interferon-gamma improves splicing efficiency of CYBB gene transcripts in an interferon-responsive variant of chronic granulomatous disease due to a splice site consensus region mutation
Blood, June 1, 2000; 95(11): 3548 - 3554.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. G. Hamil, P. Sivashanmugam, R. T. Richardson, G. Grossman, S. M. Ruben, J. L. Mohler, P. Petrusz, M. G. O'Rand, F. S. French, and S. H. Hall
HE2{beta} and HE2{gamma}, New Members of an Epididymis-Specific Family of Androgen-Regulated Proteins in the Human
Endocrinology, March 1, 2000; 141(3): 1245 - 1253.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Colman-Lerner, M. L. Fischman, G. M. Lanuza, D. M. Bissell, A. R. Kornblihtt, and J. L. Barañao
Evidence for a Role of the Alternatively Spliced ED-I Sequence of Fibronectin during Ovarian Follicular Development
Endocrinology, June 1, 1999; 140(6): 2541 - 2548.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
A. F. Muro, M. Caputi, R. Pariyarath, F. Pagani, E. Buratti, and F. E. Baralle
Regulation of Fibronectin EDA Exon Alternative Splicing: Possible Role of RNA Secondary Structure for Enhancer Display
Mol. Cell. Biol., April 1, 1999; 19(4): 2657 - 2671.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. J. Avila, P. A. Lympany, P. Pantelidis, K. I. Welsh, C. M. Black, and R. M. du Bois
Fibronectin Gene Polymorphisms Associated with Fibrosing Alveolitis in Systemic Sclerosis
Am. J. Respir. Cell Mol. Biol., January 1, 1999; 20(1): 106 - 112.
[Abstract] [Full Text]

Home page
 J. Cell Biol.Home page
G. Serini, M.-L. Bochaton-Piallat, P. Ropraz, A. Geinoz, L. Borsi, L. Zardi, and G. Gabbiani
The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-beta 1
J. Cell Biol., August 10, 1998; 142(3): 873 - 881.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. P. Lim and P. A. Sharp
Alternative Splicing of the Fibronectin EIIIB Exon Depends on Specific TGCATG Repeats
Mol. Cell. Biol., July 1, 1998; 18(7): 3900 - 3906.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
A. Staffa, N. H. Acheson, and A. Cochrane
Novel Exonic Elements That Modulate Splicing of the Human Fibronectin EDA Exon
J. Biol. Chem., December 26, 1997; 272(52): 33394 - 33401.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Romano, P. Dri, L. Dadalt, P. Patriarca, and F. E. Baralle
Biochemical and Molecular Characterization of Hereditary Myeloperoxidase Deficiency
Blood, November 15, 1997; 90(10): 4126 - 4134.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. L. George, H. S. Baldwin, and R. O. Hynes
Fibronectins Are Essential for Heart and Blood Vessel Morphogenesis But Are Dispensable for Initial Specification of Precursor Cells
Blood, October 15, 1997; 90(8): 3073 - 3081.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Cramer, C. G. Pesce, F. E. Baralle, and A. R. Kornblihtt
Functional association between promoter structure and transcript alternative splicing
PNAS, October 14, 1997; 94(21): 11456 - 11460.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. h. Sun, M. Mitnick, C. Eielson, G. Q. Yao, I. Paliwal, and K. Insogna
Parathyroid Hormone Increases Circulating Levels of Fibronectin in Vivo: Modulating Effect of Ovariectomy
Endocrinology, September 1, 1997; 138(9): 3918 - 3924.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
F. W. Dunn, M.-H. Roux, F. Farhadian, K. Sabri, C. Ossart, J. L. Samuel, L. Rappaport, and G. Hamon
HR 720, A Novel Angiotensin Receptor Antagonist Inhibits the Angiotensin II-Induced Trophic Effects, Fibronectin Release and Fibronectin-EIIIA+ Expression in Rat Aortic Vascular Smooth Muscle Cells in Vitro
J. Pharmacol. Exp. Ther., January 1, 1997; 280(1): 447 - 453.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
C. R. Alonso, C. G. Pesce, and A. R. Kornblihtt
The CCAAT-binding Proteins CP1 and NF-I Cooperate with ATF-2 in the Transcription of the Fibronectin Gene
J. Biol. Chem., September 6, 1996; 271(36): 22271 - 22279.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Liu, J. Yao, D. Mercola, and E. Adamson
The Transcription Factor EGR-1 Directly Transactivates the Fibronectin Gene and Enhances Attachment of Human Glioblastoma Cell Line U251
J. Biol. Chem., June 30, 2000; 275(27): 20315 - 20323.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by The Federation of American Societies for Experimental Biology.