FASEB J. Thermo Fisher Scientific
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Probst, J. C.
Right arrow Articles by Jirikowski, G. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Probst, J. C.
Right arrow Articles by Jirikowski, G. F.

The FASEB Journal, Vol 10, 1518-1523, Copyright © 1996 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Human intestinal trefoil factor is expressed in human hypothalamus and pituitary: evidence for a novel neuropeptide

JC Probst, T Zetzsche, M Weber, P Theilemann, T Skutella, R Landgraf and GF Jirikowski
Max Planck Institute of Psychiatry, Clinical Institute, Department of Neuroendocrinology, Munich, Germany.

Human intestinal trefoil factor, hITF, a secretory polypeptide found mainly in the human gastrointestinal tract, is a member of the newly characterized trefoil factor or P-domain peptide family representing putative growth factors. Here we describe the identification of this gut peptide in the human brain and pituitary. With reverse transcriptase polymerase chain reaction, we were able to isolate and clone the transcript from human hypothalamus. An antibody generated against a synthetic peptide derived from the carboxyl terminus of hITF was used for immunohistochemical studies of appropriate tissue sections. Neurons expressing hITF were identified in two magnocellular hypothalamic nuclei, the paraventricular and periventricular nuclei. hITF polypeptide was also observed in Herring bodies of the neurohypophysis and in secretory cells of the adenohypophysis. Double immunostaining with antigrowth hormone antibody showed partial coexistence in a selected subpopulation of adenohypophysial cells. Localization of hITF in the hypothalamo-neurohypophysial system may suggest a modulatory action on the classical magnocellular nonapeptides vasopressin and oxytocin, and further indicates an adenohypophysial importance of this peptide. It is likely that hITF represents a novel neuropeptide of yet unknown function.


This article has been cited by other articles:


Home page
 FASEB J.Home page
S. RODRIGUES, Q.-D. NGUYEN, S. FAIVRE, E. BRUYNEEL, L. THIM, B. WESTLEY, F. MAY, G. FLATAU, M. MAREEL, C. GESPACH, et al.
Activation of cellular invasion by trefoil peptides and src is mediated by cyclooxygenase- and thromboxane A2 receptor-dependent signaling pathways
FASEB J, July 1, 2001; 15(9): 1517 - 1528.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
W. JAGLA, A. WIEDE, K. DIETZMANN, K. RUTKOWSKI, and W. HOFFMANN
Co-localization of TFF3 peptide and oxytocin in the human hypothalamus
FASEB J, June 1, 2000; 14(9): 1126 - 1131.
[Abstract] [Full Text]

Home page
 J. Cell Sci.Home page
X. Tan, Y. Chen, Q. Liu, F Gonzalez-Crussi, and X. Liu
Prostanoids mediate the protective effect of trefoil factor 3 in oxidant-induced intestinal epithelial cell injury: role of cyclooxygenase-2
J. Cell Sci., January 6, 2000; 113(12): 2149 - 2155.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by The Federation of American Societies for Experimental Biology.