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The FASEB Journal, Vol 10, 1464-1470, Copyright © 1996 by The Federation of American Societies for Experimental Biology

REVIEWS

Human fibrinogen: anticipating a 3-dimensional structure

RF Doolittle, SJ Everse and G Spraggon
Center for Molecular Genetics, University of California, San Diego, La Jolla 92093-0634, USA.

The principal component of blood clots is a protein meshwork called fibrin. The precursor protein, fibrinogen, occurs in a soluble form in the blood plasma where it is activated by thrombin when and if the need arises. More than a century after first being purified, fibrinogen has yet to have its detailed 3-dimensional structure revealed. The situation is changing rapidly, however, and crystallographic studies in progress in several laboratories on a variety of fragments and complexes may soon reveal not only its structure but also the subtleties of how this large glycoprotein is transformed into a fibrin clot.


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Copyright © 1996 by The Federation of American Societies for Experimental Biology.