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The FASEB Journal, Vol 1, 469-473, Copyright © 1987 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Ethanol: an enhancer of major histocompatibility complex antigen expression

LJ Parent, R Ehrlich, L Matis and DS Singer
Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892.

Ethanol enhances expression of cell surface class I major histocompatibility complex (MHC) antigens in a variety of cell lines; up to an eightfold increase is observed in an embryonic cell line. In ethanol-treated L cells, increased cell surface expression of MHC antigens occurs with a concomitant increase in steady-state RNA levels. This effect is promoter dependent and restricted, because not all gene products are elevated. The effective ethanol concentration (1%) is physiologically attainable, leading to speculations about the role of elevated MHC antigens in alcohol-related diseases.


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N. Wilke, M. W. Sganga, G. G. Gayer, K.-P. Hsieh, and M. F. Miles
Characterization of Promoter Elements Mediating Ethanol Regulation of hsc70 Gene Transcription
J. Pharmacol. Exp. Ther., January 1, 2000; 292(1): 173 - 180.
[Abstract] [Full Text]


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Copyright © 1987 by The Federation of American Societies for Experimental Biology.