The FASEB Journal, Vol 1, 456-461, Copyright © 1987 by The Federation of American Societies for Experimental Biology

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Interleukin 4/B cell stimulatory factor 1: one lymphokine, many functions

WE Paul
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

Lymphokines are multifunctional T cell products that profoundly regulate the activation, growth, and differentiation of many cell types, most notably T cells and B cells. One of the lymphokines with the broadest range of actions is interleukin 4/B cell stimulatory factor 1. The characteristics, function, and regulation of interleukin 4 are reviewed as part of an overall discussion of the mechanism through which T cell-derived lymphokines control immune responses in vivo and in vitro.

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