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The FASEB Journal, Vol 1, 116-118, Copyright © 1987 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Inhibition of induced acute lung edema by a novel protein kinase C inhibitor

D Struhar and RJ Harbeck

The effect of the protein kinase C enzyme inhibitor H-7 on the noncardiogenic lung edema induced by phorbol myristate acetate (PMA) in mice was examined. Lung edema was assessed by measurement of 125I- labeled albumin leak into the lung. The results showed that pretreatment of mice with H-7 nearly prevents the albumin leak induced by PMA, whereas post-PMA treatment with H-7 had less of an effect on the albumin leak, although it was still significant.


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Copyright © 1987 by The Federation of American Societies for Experimental Biology.