FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Russell, P.
Right arrow Articles by Breitman, M. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Russell, P.
Right arrow Articles by Breitman, M. L.

The FASEB Journal, Vol 1, 32-35, Copyright © 1987 by The Federation of American Societies for Experimental Biology

RESEARCH COMMUNICATIONS

Aging effects of vitamin C on a human lens protein produced in vitro

P Russell, D Garland, JS Zigler Jr, SO Meakin, LC Tsui and ML Breitman

Human lens gamma-crystallin obtained from the expression of a gene construct stably integrated into mouse L cells was incubated with ascorbate in the presence of iron and oxygen. The resulting oxidation of the gamma-crystallin led to more acidic species of this protein. These alterations were similar to the changes seen with aging in the human lens. The results suggest that oxidation of lens crystallins may be responsible for the changes seen on aging and cataract development and that ascorbate may contribute to these alterations.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
P. J. Muchowski, J. A. Bassuk, N. H. Lubsen, and J. I. Clark
Human alpha B-Crystallin. SMALL HEAT SHOCK PROTEIN AND MOLECULAR CHAPERONE
J. Biol. Chem., January 24, 1997; 272(4): 2578 - 2582.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1987 by The Federation of American Societies for Experimental Biology.