| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
E-mail contact: douglas.noonan{at}uninsubria.it
Xanthohumol (XN), the principal flavonoid of the hop plant (Humulus lupulus L.) and a constituent of beer, has been suggested to have potential cancer chemopreventive activities. We have observed that most cancer chemopreventive agents show antiangiogenic properties in vitro and in vivo, a concept we termed "angioprevention." Here we show for the first time that XN can inhibit growth of a vascular tumor in vivo. Histopathology and in vivo angiogenesis assays indicated that tumor angiogenesis inhibition was involved. Further, we show the mechanisms for its inhibition of angiogenesis in vivo and related endothelial cell activities in vitro. XN repressed both the NF-κB and Akt pathways in endothelial cells, indicating that components of these pathways are major targets in the molecular mechanism of XN. Moreover, using in vitro analyses, we show that XN interferes with several points in the angiogenic process, including inhibition of endothelial cell invasion and migration, growth, and formation of a network of tubular-like structures. Our results suggest that XN can be added to the expanding list of antiangiogenic chemopreventive drugs whose potential in cancer prevention and therapy should be evaluated.
Key words: angioprevention • chemoprevention • endothelial cells • NF-κB • Akt
This article has been cited by other articles:
|
|
 |
|
  A. Albini, G. Pennesi, F. Donatelli, R. Cammarota, S. De Flora, and D. M. Noonan Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention J Natl Cancer Inst, January 6, 2010; 102(1): 14 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. B. Harikumar, A. B. Kunnumakkara, K. S. Ahn, P. Anand, S. Krishnan, S. Guha, and B. B. Aggarwal Modification of the cysteine residues in I{kappa}B{alpha} kinase and NF-{kappa}B (p65) by xanthohumol leads to suppression of NF-{kappa}B-regulated gene products and potentiation of apoptosis in leukemia cells Blood, February 26, 2009; 113(9): 2003 - 2013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jain, G. Chakraborty, R. Raja, S. Kale, and G. C. Kundu Prostaglandin E2 Regulates Tumor Angiogenesis in Prostate Cancer Cancer Res., October 1, 2008; 68(19): 7750 - 7759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Vene, P. Larghero, G. Arena, M. B. Sporn, A. Albini, and F. Tosetti Glycogen Synthase Kinase 3{beta} Regulates Cell Death Induced by Synthetic Triterpenoids Cancer Res., September 1, 2008; 68(17): 6987 - 6996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Monteghirfo, F. Tosetti, C. Ambrosini, S. Stigliani, S. Pozzi, F. Frassoni, G. Fassina, S. Soverini, A. Albini, and N. Ferrari Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-{kappa}B and p53 modulation Mol. Cancer Ther., September 1, 2008; 7(9): 2692 - 2702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Baron-Menguy, A. Bocquet, A.-L. Guihot, D. Chappard, M.-J. Amiot, R. Andriantsitohaina, L. Loufrani, and D. Henrion Effects of red wine polyphenols on postischemic neovascularization model in rats: low doses are proangiogenic, high doses anti-angiogenic FASEB J, November 1, 2007; 21(13): 3511 - 3521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Albini, D. M. Noonan, and N. Ferrari Molecular Pathways for Cancer Angioprevention Clin. Cancer Res., August 1, 2007; 13(15): 4320 - 4325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Larghero, R. Vene, S. Minghelli, G. Travaini, M. Morini, N. Ferrari, U. Pfeffer, D. M. Noonan, A. Albini, and R. Benelli Biological assays and genomic analysis reveal lipoic acid modulation of endothelial cell behavior and gene expression Carcinogenesis, May 1, 2007; 28(5): 1008 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Speakers' abstracts Ann Rheum Dis, March 1, 2007; 66(suppl_1): A1 - A5. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
