Figure 2. Schematic diagram of the effects of heme oxygenase-1 (HO-1) localized in the mitochondria on cytochrome oxidase (COX) subunit I and mitochondrial targeted NOS (mtNOS). Induction of mitochondrial HO-1 was associated with a decrease of mitochondrial heme content resulting in a reduction in protein expression of heme-containing cytochrome oxidase (COX) subunit I and mtNOS.