Figure 3. A proposed model depicting the role of Hsp90 in regulating the activity of LIMK1 and LIMK2. Hsp90 binding to a motif in the kinase domain of LIMK promotes a complex between two LIMK molecules facilitating transphosphorylation and stabilization of LIMK. After transphosphorylation, the complex between LIMK and Hsp90 is disrupted allowing LIMK interaction with its substrate cofilin.