Click on image to view larger version.


Figure 3


Figure 3. Schematic diagram. Proposed mechanism for PPAR{gamma} agonist-induced edema and weight gain through protein kinase C (PKC)-mediated increase in vascular permeability of adipose tissue. DAG, diacylglycerol; PKC, protein kinase C; VEGF, vascular endothelial growth factor; ruboxistaurin, PKCß isoform selective inhibitor.