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Researchers discover molecular basis of a form of muscular dystrophy
New study in the FASEB Journal identifies c-FLIP and calpain-3 proteins as drug targets in limb-girdle muscular dystrophy and other conditions
A team of French and German researchers report in the May 2008 print issue of The FASEB Journal (http://www.fasebj.org) that people with limb-girdle muscular dystrophy are missing a protein called c-FLIP, which the body uses to prevent the loss of muscle tissue. By targeting the cellular and molecular mechanisms responsible for creating this protein, scientists could develop new drugs to stop muscle wasting from limb-girdle muscular dystrophy and other conditions. [View Release]

News Archive
Essential nutrient found in eggs reduces risk of breast cancer by 24 percent
Most Women in the U.S. Consume Too Little Choline
PARK RIDGE, Ill., April 3, 2008 /PRNewswire/ -- Choline, an essential nutrient found in foods such as eggs, is associated with a 24 percent reduced risk of breast cancer, according to a study supported by a grant from the U.S. National Institutes of Health, to be published in The FASEB Journal's June 2008 print issue. This study adds to the growing body of evidence that links egg consumption to a decreased risk of breast cancer. "While choline is an essential nutrient to the human diet, most people haven't even heard of it," says Gerald Weissmann, MD, Editor in Chief of The FASEB Journal. "Given that in the U.S. there is a real need to understand how much choline we require in our diet, we hope that research, education and awareness about choline will increase as a result of this study published in The FASEB Journal." [View Release]

Harvard researchers publish MRI images of genes in action in the living brain
New study in The FASEB Journal describes the delivery of brain probes by eye drop
Biologists have just confirmed what poets have known for centuries: eyes really are windows of the soul—or at least of the brain. In a new study published in the April 2008 print issue of The FASEB Journal (http://www.fasebj.org), Harvard researchers describe the development of gene probe eye drops that—for the first time—make it possible to monitor and detect tissue repair in the brain of living organisms using MRI. Current methods involve a risky, invasive, and relatively slow process of penetrating the skull to extract tissue samples and then examining those samples in a laboratory. [View Release]

Scientists discover how cigarette smoke causes cancer: study points to new treatments
Everyone has known for decades that that smoking can kill, but until now no one really understood how cigarette smoke causes healthy lung cells to become cancerous. In a new research report published in the March 2008 print issue of The FASEB Journal (http://www.fasebj.org), researchers from the University of California, Davis, show that hydrogen peroxide (or similar oxidants) in cigarette smoke is the culprit. This finding may give medical researchers a new avenue to developing lung cancer treatments. [View Release]

Pharmaceutical breakthrough may make a range of drugs cheaper and more available
Scientists use gene therapy to cause goats to produce therapeutic proteins in their milk
A new study published in the February 2008 print edition of The FASEB Journal describes a scientific advance that should reduce the cost and increase the availability of a wide range of drugs. In the report, University of Pennsylvania researchers describe how they used gene therapy to reduce the time it takes to breed large animals capable of producing therapeutic proteins in their milk, such as insulin or those that fight cancer. This represents a significant milestone in drug development.  [View Release]

 Porous structures help boost integration of host tissue with implants, study finds
Results published  in The FASEB Journal by researchers at Columbia University demonstrate a novel way of using porous structures as a drug-delivery vehicle that can help boost the integration of host tissue with surgically implanted titanium. Instead of being acted upon by the body as an impenetrable foreign object, the synthetic bone replacement – currently being tested in rabbits – features a porous material that allows for the delivery of “microencapsulated bioactive cues” that speed up the growth of host tissue at the site and allow for the growth of new bone. A critical finding is that the drug dose needed for host tissue integration by this controlled-release approach is about 1/10 of that by the traditional technique of simple adsorption of the growth factor. The approach could bring to orthopedics and dentistry a treatment that has wrought much interest and success in the field of cardiology with the development of drug-eluting stents, which take what is ordinarily an inert tube, and infuse it with drugs to make the placement of what is essentially a man-made, foreign object more compatible with the patient’s body, and at the same time, actively promoting healing of injured tissue. After just four weeks, the porous implants that the research team are using showed a 96 percent increase in bone-to-implant contact and a 50 percent increase in the growth of new bone over placebos.
How were such results achieved? [View Release]

 New discovery could reduce the health risk of high-fat foods
Chemical in red wine, fruits and vegetables counters unhealthy effects of high-fat foods
Just as additives help gasoline burn cleaner, a research report published in the January 2008 print issue of The FASEB Journal shows that the food industry could take a similar approach toward reducing health risks associated with fatty foods. These “meal additives” would be based on work of Israeli researchers who discovered that consuming polyphenols (natural compounds in red wine, fruits, and vegetables) simultaneously with high-fat foods may reduce health risks associated with these foods.  [View Release]

  Evolution education is a 'must' says coalition of scientific and teaching organizations
Seventeen organizations report on national survey to determine public views of evolution education
A coalition of 17 organizations, including the National Academy of Sciences, the American Institute of Physics, and the National Science Teachers Association, is calling on the scientific community to become more involved in the promotion of science education, including evolution. According to an article appearing in the January 2008 issue of The FASEB Journal, the introduction of “non-science,” such as creationism and intelligent design, into science education will undermine the fundamentals of science education. Some of these fundamentals include using the scientific method, understanding how to reach scientific consensus, and distinguishing between scientific and nonscientific explanations of natural phenomena..  [View Release]

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